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    her-1 Protein her-1 [ Caenorhabditis elegans ]

    Gene ID: 179360, updated on 9-Dec-2024

    Summary

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    Official Symbol
    her-1
    Official Full Name
    Protein her-1
    Primary source
    WormBase:WBGene00001842
    Locus tag
    CELE_ZK287.8
    See related
    AllianceGenome:WB:WBGene00001842
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables signaling receptor binding activity. Involved in male sex determination. Located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See her-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (9697015..9702035)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RNA_ligase domain-containing protein Neighboring gene Protein lifeguard 1-like Neighboring gene Transmembrane BAX inhibitor motif-containing protein 4 Neighboring gene tRNA wybutosine-synthesizing protein 2 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequenced alleles of the Caenorhabditis elegans sex-determining gene her-1 include a novel class of conditional promoter mutations. Perry MD, et al. Genetics, 1994 Oct. PMID 7828816, Free PMC Article
    2. A Simple Method for Visualization of Locus-Specific H4K20me1 Modifications in Living Caenorhabditis elegans Single Cells. Shinkai Y, et al. G3 (Bethesda), 2018 Jul 2. PMID 29724885, Free PMC Article
    3. A novel dominant transformer allele of the sex-determining gene her-1 of Caenorhabditis elegans. Trent C, et al. Genetics, 1988 Sep. PMID 3220248, Free PMC Article
    4. Structure of the RECK CC domain, an evolutionary anomaly. Chang TH, et al. Proc Natl Acad Sci U S A, 2020 Jun 30. PMID 32541044, Free PMC Article
    5. Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A. Hamaoka BY, et al. Proc Natl Acad Sci U S A, 2004 Aug 10. PMID 15289613, Free PMC Article

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in male sex determination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male sex determination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in male sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein her-1
    NP_001024310.1
    • Confirmed by transcript evidence
    NP_001024311.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9697015..9702035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029139.3 → NP_001024310.1  Protein her-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024310.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34704
      Conserved Domains (1) summary
      pfam09232
      Location:32 → 162
      Caenor_Her-1; Caenorhabditis elegans Her-1

    2. NM_001029140.5 → NP_001024311.2  Protein her-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024311.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q65ZB2
      Conserved Domains (1) summary
      pfam09232
      Location:1 → 51
      Caenor_Her-1; Caenorhabditis elegans Her-1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34704.1

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