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    zak-1 Mitogen-activated protein kinase kinase kinase zak-1 [ Caenorhabditis elegans ]

    Gene ID: 175954, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zak-1
    Official Full Name
    Mitogen-activated protein kinase kinase kinase zak-1
    Primary source
    WormBase:WBGene00006971
    Locus tag
    CELE_R13F6.6
    See related
    AllianceGenome:WB:WBGene00006971
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables MAP kinase kinase kinase activity. Involved in stress-activated MAPK cascade. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See zak-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (6853101..6856809, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene EGF-like domain-containing protein;Teneurin-1;Tox-GHH domain-containing protein Neighboring gene ncRNA Neighboring gene Palmitoyltransferase Neighboring gene Serpentine receptor class V-1 Neighboring gene C-type lectin domain-containing protein 158 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains. Vind AC, et al. Mol Cell, 2020 May 21. PMID 32289254
    2. Roles of MAP kinase cascades in Caenorhabditis elegans. Sakaguchi A, et al. J Biochem, 2004 Jul. PMID 15269234
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mitogen-activated protein kinase kinase kinase zak-1
    NP_001367790.1
    • Confirmed by transcript evidence
    NP_001367792.1
    • Confirmed by transcript evidence
    NP_001379904.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6853101..6856809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392131.1 → NP_001379904.1  Mitogen-activated protein kinase kinase kinase zak-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl15755
      Location:51 → 112
      SAM_superfamily; SAM (Sterile alpha motif )

    2. NM_001379779.2 → NP_001367792.1  Mitogen-activated protein kinase kinase kinase zak-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      PRK00409
      Location:105 → 154
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      cl15755
      Location:171 → 232
      SAM_superfamily; SAM (Sterile alpha motif )
      cl21453
      Location:9 → 85
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001379778.1 → NP_001367790.1  Mitogen-activated protein kinase kinase kinase zak-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2KZW3, H2KZW5, Q8I7J0
      Conserved Domains (1) summary
      cl21453
      Location:38 → 291
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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