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    gst-43 maleylacetoacetate isomerase [ Caenorhabditis elegans ]

    Gene ID: 190586, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gst-43
    Official Full Name
    maleylacetoacetate isomerase
    Primary source
    WormBase:WBGene00001791
    Locus tag
    CELE_Y71F9AL.5
    See related
    AllianceGenome:WB:WBGene00001791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutathione transferase activity and maleylacetoacetate isomerase activity. Predicted to be involved in L-phenylalanine catabolic process and glutathione metabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Orthologous to human GSTZ1 (glutathione S-transferase zeta 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gst-43 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (2901325..2903006)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Actin-related protein 3 Neighboring gene Protein PBN1 Neighboring gene Coatomer subunit alpha Neighboring gene Tyrosine-protein phosphatase Neighboring gene Poly [ADP-ribose] polymerase;Poly [ADP-ribose] polymerase 1 Neighboring gene Protein kinase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables maleylacetoacetate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables maleylacetoacetate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tyrosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    maleylacetoacetate isomerase
    NP_491070.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2901325..2903006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058669.4 → NP_491070.1  maleylacetoacetate isomerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491070.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4H6
      Conserved Domains (3) summary
      cd03191
      Location:90 → 207
      GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
      cd03042
      Location:4 → 77
      GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      TIGR01262
      Location:5 → 211
      maiA; maleylacetoacetate isomerase
    Nucleotide Protein
    Heading Accession and Version

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