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    slc-25A32 Mitochondrial folate transporter/carrier [ Caenorhabditis elegans ]

    Gene ID: 186841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc-25A32
    Official Full Name
    Mitochondrial folate transporter/carrier
    Primary source
    WormBase:WBGene00010459
    Locus tag
    CELE_K01C8.7
    See related
    AllianceGenome:WB:WBGene00010459
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable FAD transmembrane transporter activity and folic acid transmembrane transporter activity. Predicted to be involved in folate import into mitochondrion. Predicted to be located in cytoplasm; intracellular membrane-bounded organelle; and membrane. Predicted to be active in mitochondrion. Orthologous to human SLC25A32 (solute carrier family 25 member 32). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See slc-25A32 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (8276298..8277621)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Tyrosine decarboxylase Neighboring gene GEX Interacting protein Neighboring gene Large ribosomal subunit protein uL10m Neighboring gene C-type lectin domain-containing protein Neighboring gene Guanine nucleotide-binding protein-like 3 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables FAD transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables folic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in FAD transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in folate import into mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mitochondrial folate transporter/carrier
    NP_001122619.1
    • Confirmed by transcript evidence
    NP_495746.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8276298..8277621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063345.6 → NP_495746.1  Mitochondrial folate transporter/carrier [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495746.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21084
      Conserved Domains (2) summary
      PTZ00169
      Location:12 → 290
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:5 → 100
      Mito_carr; Mitochondrial carrier protein

    2. NM_001129147.5 → NP_001122619.1  Mitochondrial folate transporter/carrier [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122619.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5JYR3
      Conserved Domains (1) summary
      pfam00153
      Location:5 → 100
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version

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