dro-1 Protein Dr1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dro-1
Official Full Name: Protein Dr1
Primary source: WormBase:WBGene00001092
Locus tag: CELE_F53A2.5
See related: AllianceGenome:WB:WBGene00001092
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA polymerase II general transcription initiation factor activity and TBP-class protein binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to be located in nucleus. Predicted to be part of negative cofactor 2 complex. Orthologous to human DR1 (down-regulator of transcription 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dro-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 2

Sequence:: Chromosome: III; NC_003281.10 (13342684..13343712)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F53A2.4 (e-PCR)
- UniSTS:321496

F53A2.5 (e-PCR)
- UniSTS:320729

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables TBP-class protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of negative cofactor 2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of negative cofactor 2 complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein Dr1

NP_001379209.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

13342684..13343712

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392227.1 → NP_001379209.1 Protein Dr1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

O45550

Conserved Domains (1) summary

cl23735
Location:13 → 143

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...