dhp-2 Dihydropyrimidinase 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dhp-2
Official Full Name: Dihydropyrimidinase 2
Primary source: WormBase:WBGene00000964
Locus tag: CELE_C47E12.8
See related: AllianceGenome:WB:WBGene00000964
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. Involved in pyrimidine nucleobase catabolic process. Located in cytoplasm. Is expressed in body wall musculature. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome; dihydropyrimidinase deficiency; and purine-pyrimidine metabolic disorder. Orthologous to several human genes including DPYS (dihydropyrimidinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dhp-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (9978122..9980775)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C47E12.8 (e-PCR)
- UniSTS:321290

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables dihydropyrimidinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydropyrimidinase activity	IEA Inferred from Electronic Annotation more info
enables dihydropyrimidinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nucleobase catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in pyrimidine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine nucleobase catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Dihydropyrimidinase 2

NP_501797.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9978122..9980775

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069396.8 → NP_501797.1 Dihydropyrimidinase 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501797.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18677

Conserved Domains (2) summary

PRK09060
Location:3 → 446

PRK09060; dihydroorotase; Validated

cd01314
Location:3 → 453

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...