sorf-2 Suppressor of organelle fusion 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sorf-2
Official Full Name: Suppressor of organelle fusion 2
Primary source: WormBase:WBGene00018672
Locus tag: CELE_F52C9.1
See related: AllianceGenome:WB:WBGene00018672
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable phosphatidylinositol 3-kinase inhibitor activity. Involved in organelle fusion and positive regulation of early endosome to late endosome transport. Located in early endosome and late endosome. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2 and hydrocephalus. Orthologous to human WDR81 (WD repeat domain 81). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sorf-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 16

Sequence:: Chromosome: III; NC_003281.10 (5326623..5333620)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SORF-1 and SORF-2 are essential for appropriate maintenance of PtdIns3P levels in early-to-late endosome conversion
Title: Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F52C9.1 (e-PCR)
- UniSTS:311711

F52C9.3 (e-PCR)
- UniSTS:311712

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphatidylinositol 3-kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in early endosome to late endosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in organelle fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of early endosome to late endosome transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of early endosome to late endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Suppressor of organelle fusion 2

NP_001367877.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5326623..5333620

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001379708.3 → NP_001367877.1 Suppressor of organelle fusion 2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

D7SFK0, Q10122, Q45EK8, Q45EK9

Conserved Domains (3) summary

smart01026
Location:236 → 463

Beach; Beige/BEACH domain

sd00039
Location:1099 → 1139

7WD40; WD40 repeat [structural motif]

cl29593
Location:1062 → 1292

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...