prp-4 Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: prp-4
Official Full Name: Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein
Primary source: WormBase:WBGene00007972
Locus tag: CELE_C36B1.5
See related: AllianceGenome:WB:WBGene00007972
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable U4 snRNA binding activity and U6 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U4/U6 x U5 tri-snRNP complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 70. Orthologous to human PRPF4 (pre-mRNA splicing tri-snRNP complex factor PRPF4). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See prp-4 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (8733413..8735717, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

C36B1.5 (e-PCR)
- UniSTS:309263

C36B1.7 (e-PCR)
- UniSTS:321973

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables U4 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U6 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of U4/U6 x U5 tri-snRNP complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein

NP_492363.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8733413..8735717 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059962.4 → NP_492363.1 Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492363.1

Status: REVIEWED

UniProtKB/TrEMBL

Q93339

Conserved Domains (3) summary

smart00500
Location:76 → 115

SFM; Splicing Factor Motif, present in Prp18 and Pr04

cd00200
Location:191 → 492

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:207 → 244

7WD40; WD40 repeat [structural motif]