unc-55 Nuclear hormone receptor unc-55 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-55
Official Full Name: Nuclear hormone receptor unc-55
Primary source: WormBase:WBGene00006790
Locus tag: CELE_F55D12.4
See related: AllianceGenome:WB:WBGene00006790
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in cell fate specification; negative regulation of transcription by RNA polymerase II; and neuron remodeling. Predicted to be active in nucleus. Is expressed in motor neurons; somatic nervous system; and spicule muscle. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5 and Bosch-Boonstra-Schaaf optic atrophy syndrome. Orthologous to several human genes including NR2F1 (nuclear receptor subfamily 2 group F member 1) and NR2F2 (nuclear receptor subfamily 2 group F member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-55 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (7898434..7903334, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CoupTFII/UNC-55 differentiates specific GABAergic motor neuron subtypes. The unc-55 promoter contains distinct regions required for expression/repression. Different Meis/UNC-62 isoforms act through specific regions of the unc-55 promoter. UNC-62 isoforms differentially regulate the mRNA and protein expression of UNC-55
Title: Meis/UNC-62 isoform dependent regulation of CoupTF-II/UNC-55 and GABAergic motor neuron subtype differentiation.
Caenorhabditis elegans males require male-specifically expressed UNC-55 to execute copulatory motor programs. Isoform b represents the first report of male-specific splicing in C. elegans.
Title: Copulation in C. elegans males requires a nuclear hormone receptor.

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General gene information

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Markers

F55D12.6 (e-PCR)
- UniSTS:318264

F55D12.4 (e-PCR)
- UniSTS:314473

STS1-149 (e-PCR)
- UniSTS:241635

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear hormone receptor unc-55

NP_001122482.2

Confirmed by transcript evidence

NP_001122483.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7898434..7903334 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001129010.3 → NP_001122482.2 Nuclear hormone receptor unc-55 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122482.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECR9, G5EDI5

Conserved Domains (2) summary

cd06930
Location:148 → 325

NR_LBD_F2; Ligand-binding domain of nuclear receptor family 2

cd06958
Location:21 → 89

NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers
NM_001129011.4 → NP_001122483.2 Nuclear hormone receptor unc-55 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122483.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EDI5

Conserved Domains (2) summary

cd06930
Location:135 → 312

NR_LBD_F2; Ligand-binding domain of nuclear receptor family 2

cd06958
Location:21 → 93

NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers