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    mog-4 putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4 [ Caenorhabditis elegans ]

    Gene ID: 175117, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mog-4
    Official Full Name
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4
    Primary source
    WormBase:WBGene00003392
    Locus tag
    CELE_C04H5.6
    See related
    AllianceGenome:WB:WBGene00003392
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity and helicase activity. Involved in several processes, including embryonic body morphogenesis; feminization of hermaphroditic germ-line; and germ cell development. Predicted to be located in nucleus. Orthologous to human DHX16 (DEAH-box helicase 16). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mog-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (14552504..14561599, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein;Toxin Neighboring gene pseudo Neighboring gene Receptor-type guanylate cyclase gcy-29 Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The hermaphrodite sperm/oocyte switch requires the Caenorhabditis elegans homologs of PRP2 and PRP22. Puoti A, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737793, Free PMC Article
    2. The Caenorhabditis elegans DDX-23, a homolog of yeast splicing factor PRP28, is required for the sperm-oocyte switch and differentiation of various cell types. Konishi T, et al. Dev Dyn, 2008 Sep. PMID 18729217
    3. The MEP-1 zinc-finger protein acts with MOG DEAH box proteins to control gene expression via the fem-3 3' untranslated region in Caenorhabditis elegans. Belfiore M, et al. RNA, 2002 Jun. PMID 12088146, Free PMC Article
    4. Gametogenesis: keeping the male element under control. Kuwabara PE. Curr Biol, 1998 Apr 9. PMID 9550693
    5. Roles of the C. elegans cyclophilin-like protein MOG-6 in MEP-1 binding and germline fates. Belfiore M, et al. Development, 2004 Jun. PMID 15151984

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in feminization of hermaphroditic germ-line IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reproductive process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4
    NP_001293532.1
    • Confirmed by transcript evidence
    NP_497027.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14552504..14561599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064626.6 → NP_497027.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497027.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45239, O45244
      Conserved Domains (6) summary
      smart00487
      Location:370 → 546
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:764 → 848
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:381 → 520
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:577 → 696
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:872 → 981
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
      pfam08070
      Location:103 → 162
      DTHCT; DTHCT (NUC029) region

    2. NM_001306603.4 → NP_001293532.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293532.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PDV5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45244.2

    Gene LinkOut

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