osm-1 Intraflagellar transport protein osm-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: osm-1
Official Full Name: Intraflagellar transport protein osm-1
Primary source: WormBase:WBGene00003883
Locus tag: CELE_T27B1.1
See related: AllianceGenome:WB:WBGene00003883
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in dauer entry and non-motile cilium assembly. Located in ciliary transition zone and non-motile cilium. Part of intraciliary transport particle B. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 20; retinitis pigmentosa 71; and short-rib thoracic dysplasia 10 with or without polydactyly. Orthologous to human IFT172 (intraflagellar transport 172). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See osm-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 25

Sequence:: Chromosome: X; NC_003284.9 (16540674..16551211)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cloning of osm-1 gene, this gene affects chemotaxis and are reqiured for intraflgellar transport.
Title: The molecular identities of the Caenorhabditis elegans intraflagellar transport genes dyf-6, daf-10 and osm-1.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T27B1.1 (e-PCR)
- UniSTS:311038

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in dauer entry	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intraciliary transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary transition zone	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
part_of intraciliary transport particle B	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle B	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Intraflagellar transport protein osm-1

NP_510681.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

16540674..16551211

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078280.8 → NP_510681.4 Intraflagellar transport protein osm-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510681.4

Status: REVIEWED

UniProtKB/Swiss-Prot

Q1KYP6, Q22830

Conserved Domains (5) summary

COG2319
Location:9 → 218

WD40; WD40 repeat [General function prediction only]

COG5290
Location:746 → 1079

COG5290; IkappaB kinase complex, IKAP component [Transcription]

sd00006
Location:803 → 837

TPR; TPR repeat [structural motif]

sd00039
Location:19 → 64

7WD40; WD40 repeat [structural motif]

cl02567
Location:16 → 262

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...