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    gna-2 Glucosamine 6-phosphate N-acetyltransferase [ Caenorhabditis elegans ]

    Gene ID: 172533, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gna-2
    Official Full Name
    Glucosamine 6-phosphate N-acetyltransferase
    Primary source
    WormBase:WBGene00001647
    Locus tag
    CELE_T23G11.2
    See related
    AllianceGenome:WB:WBGene00001647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glucosamine 6-phosphate N-acetyltransferase activity. Involved in chitin biosynthetic process and eggshell formation. Predicted to be located in Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; and late endosome. Is expressed in pharynx. Orthologous to human GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gna-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (7699682..7700958)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Female germline-specific tumor suppressor gld-1 Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response. Horn M, et al. iScience, 2020 Mar 27. PMID 32086012, Free PMC Article
    2. Translation repression by GLD-1 protects its mRNA targets from nonsense-mediated mRNA decay in C. elegans. Lee MH, et al. Genes Dev, 2004 May 1. PMID 15105376, Free PMC Article
    3. Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1. Ruegenberg S, et al. Nat Commun, 2021 Apr 12. PMID 33846315, Free PMC Article
    4. Disruption of O-GlcNAc Cycling in C. elegans Perturbs Nucleotide Sugar Pools and Complex Glycans. Ghosh SK, et al. Front Endocrinol (Lausanne), 2014. PMID 25505447, Free PMC Article
    5. Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis. Schumacher B, et al. Cell, 2005 Feb 11. PMID 15707894

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucosamine 6-phosphate N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosamine 6-phosphate N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eggshell formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Glucosamine 6-phosphate N-acetyltransferase
    NP_492144.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7699682..7700958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059743.8 → NP_492144.1  Glucosamine 6-phosphate N-acetyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492144.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC27
      Conserved Domains (1) summary
      cl17182
      Location:198 → 338
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    Nucleotide Protein
    Heading Accession and Version

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