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    haf-3 ABC transmembrane type-1 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180056, updated on 9-Dec-2024

    Summary

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    Official Symbol
    haf-3
    Official Full Name
    ABC transmembrane type-1 domain-containing protein
    Primary source
    WormBase:WBGene00001813
    Locus tag
    CELE_F57A10.3
    See related
    AllianceGenome:WB:WBGene00001813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in intestine and spermatheca. Orthologous to human ABCB10 (ATP binding cassette subfamily B member 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See haf-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    14
    Sequence:
    Chromosome: V; NC_003283.11 (15760455..15766172, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Seven TM Receptor Neighboring gene Seven TM Receptor Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Major sperm protein Neighboring gene Sensor histidine kinase Neighboring gene Nuclear hormone receptor family member nhr-60

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of several ABC transporter genes in ivermectin resistance in Caenorhabditis elegans. Yan R, et al. Vet Parasitol, 2012 Dec 21. PMID 22840641
    2. Comparative genomics and adaptive selection of the ATP-binding-cassette gene family in caenorhabditis species. Zhao Z, et al. Genetics, 2007 Mar. PMID 17194779, Free PMC Article
    3. Nicotinamide mononucleotide adenylyltransferase promotes hypoxic survival by activating the mitochondrial unfolded protein response. Mao XR, et al. Cell Death Dis, 2016 Feb 25. PMID 26913604, Free PMC Article
    4. Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle. Schroeder LK, et al. Mol Biol Cell, 2007 Mar. PMID 17202409, Free PMC Article
    5. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Sundaram P, et al. Mol Biol Cell, 2006 Aug. PMID 16723499, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ABC transmembrane type-1 domain-containing protein
    NP_506927.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15760455..15766172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074526.8 → NP_506927.2  ABC transmembrane type-1 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506927.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17895
      Conserved Domains (3) summary
      COG1132
      Location:70 → 657
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      pfam00664
      Location:96 → 366
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:415 → 656
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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