rfc-1 Replication factor C subunit 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rfc-1
Official Full Name: Replication factor C subunit 1
Primary source: WormBase:WBGene00004337
Locus tag: CELE_C54G10.2
See related: AllianceGenome:WB:WBGene00004337
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity. Predicted to be involved in DNA clamp unloading; DNA repair; and DNA replication. Predicted to be part of DNA replication factor C complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in West Nile fever and congenital heart disease. Orthologous to human RFC1 (replication factor C subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rfc-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (14642667..14645979, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C54G10.2 (e-PCR)
- UniSTS:309418

STS5-220 (e-PCR)
- UniSTS:242384

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA clamp unloading	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DNA replication factor C complex	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Replication factor C subunit 1

NP_001256606.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

14642667..14645979 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269677.2 → NP_001256606.1 Replication factor C subunit 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256606.1

Status: REVIEWED

UniProtKB/TrEMBL

Q18841

Conserved Domains (3) summary

PRK04195
Location:277 → 805

PRK04195; replication factor C large subunit; Provisional

pfam00004
Location:344 → 453

AAA; ATPase family associated with various cellular activities (AAA)

pfam08519
Location:597 → 750

RFC1; Replication factor RFC1 C terminal domain