MT1E metallothionein 1E [Homo sapiens (human)] - Gene

Summary

Official Symbol: MT1Eprovided by HGNC
Official Full Name: metallothionein 1Eprovided by HGNC
Primary source: HGNC:HGNC:7397
See related: Ensembl:ENSG00000169715 MIM:156351; AllianceGenome:HGNC:7397
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MT1; MTD; MT-1E; MT-IE
Summary: Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver (RPKM 106.4), small intestine (RPKM 103.9) and 20 other tissues See more
Orthologs: all
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Genomic context

Location:: 16q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (56625781..56627112)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (62420746..62422077)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (56659693..56661024)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rare Variant in Metallothionein 1E Increases the Risk of Type 2 Diabetes in a Chinese Population.
Title: Rare Variant in Metallothionein 1E Increases the Risk of Type 2 Diabetes in a Chinese Population.
Identification of MT1E as a novel tumor suppressor in hepatocellular carcinoma.
Title: Identification of MT1E as a novel tumor suppressor in hepatocellular carcinoma.
Metallothionein Genes are Highly Expressed in Malignant Astrocytomas and Associated with Patient Survival.
Title: Metallothionein Genes are Highly Expressed in Malignant Astrocytomas and Associated with Patient Survival.
In clear cell renal cell carcinoma (RCC) MT1E, MT1G and MT1M expression was higher than that noted in other histological tumor subtypes (all P<0.0500). In addition, some associations were observed between metabolic syndromerelated clinical parameters and promoter methylation or gene expression
Title: DNA methylation of metallothionein genes is associated with the clinical features of renal cell carcinoma.
Forced MT1E expression rescues both hypersensitivity of CDKAL1 mutant cells to glycolipotoxicity and pancreatic beta-cell dysfunction in vitro and in vivo.
Title: Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E.
MT1E can enhance the migration and invasion of human glioma cells by inducing MMP-9 inactivation via the upregulation of NF-kappaB p50.
Title: Role of metallothionein 1E in the migration and invasion of human glioma cell lines.
Our results reveal that menopause influences the adipose tissue expression of many genes, especially of neurexin 3, metallothionein 1E, and keratyn 7, which are associated with the alteration of several key biological processes.
Title: Profile of adipose tissue gene expression in premenopausal and postmenopausal women: site-specific differences.
MT1E is a potential tumour suppressor gene, whose loss may promote resistance to apoptosis-inducing therapies.
Title: Metallothionein 1E is methylated in malignant melanoma and increases sensitivity to cisplatin-induced apoptosis.
Increases in MT gene expression and intracellular zinc levels may contribute directly to maintenance of an immune-activated monocyte by mediating an increased resistance to apoptosis during active HIV-1 viremia.
Title: Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia.
High frequency of hypermethylation of MT-1E was found in endometrial carcinomas.
Title: Epigenetic alteration of the metallothionein 1E gene in human endometrial carcinomas.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to cadmium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in detoxification of copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of growth	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: metallothionein-1E

Names: metallothionein 1E (functional); metallothionein D; metallothionein-IE

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363555.2 → NP_001350484.1 metallothionein-1E isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF495759, BC131609

Consensus CDS

CCDS86530.1

Related

ENSP00000328137.6, ENST00000330439.7

Conserved Domains (1) summary

cl19543
Location:4 → 35

Metallothio; Metallothionein
NM_175617.4 → NP_783316.2 metallothionein-1E isoform 2

See identical proteins and their annotated locations for NP_783316.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses alternate splice sites in the 3' coding region compared to variant 1, resulting in a frameshift. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

BC009699

Consensus CDS

CCDS10764.2

UniProtKB/Swiss-Prot

A2RRF7, P04732, Q86YX4, Q8TD51

Related

ENSP00000307706.5, ENST00000306061.10

Conserved Domains (1) summary

pfam00131
Location:4 → 61

Metallothio; Metallothionein