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    NUD1 Nud1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854555, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NUD1
    Official Full Name
    Nud1p
    Primary source
    SGD:S000005900
    Locus tag
    YOR373W
    See related
    AllianceGenome:SGD:S000005900; FungiDB:YOR373W; VEuPathDB:YOR373W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables signaling adaptor activity. Involved in meiotic chromosome segregation; microtubule cytoskeleton organization; and positive regulation of exit from mitosis. Located in outer plaque of mitotic spindle pole body and peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NUD1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (1036834..1039389)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Gpb1p Neighboring gene Ndd1p Neighboring gene aldehyde dehydrogenase (NADP(+)) ALD4 Neighboring gene glutamate dehydrogenase (NADP(+)) GDH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhanced protein export in Saccharomyces cerevisiae nud1 mutants is an active process. Pesheva MG, et al. Curr Microbiol, 2006 Dec. PMID 17072669
    2. Protein release in a Saccharomyces cerevisiae mutant does not depend on mitochondrial genome integrity and function. Zasheva D, et al. Microbiol Res, 2005. PMID 16035232
    3. Characterization of a Saccharomyces cerevisiae thermosensitive lytic mutant leads to the identification of a new allele of the NUD1 gene. Alexandar I, et al. Int J Biochem Cell Biol, 2004 Nov. PMID 15313466
    4. Nud1p, the yeast homolog of Centriolin, regulates spindle pole body inheritance in meiosis. Gordon O, et al. EMBO J, 2006 Aug 23. PMID 16888627, Free PMC Article
    5. A Novel Hyperactive Nud1 Mitotic Exit Network Scaffold Causes Spindle Position Checkpoint Bypass in Budding Yeast. Vannini M, et al. Cells, 2021 Dec 24. PMID 35011608, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. single amino acid mutation in NUD1 is critical, and there is a link between cell cycle progression and cellular integrity.
      Title: Characterization of a Saccharomyces cerevisiae thermosensitive lytic mutant leads to the identification of a new allele of the NUD1 gene.
    2. Functions of Nud1p are connected to the ability of Spc72p to bind to the outer plaque and half-bridge (via Kar1p) of the SPB.
      Title: Nud1p, the yeast homolog of Centriolin, regulates spindle pole body inheritance in meiosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables signaling adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in astral microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of spindle localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in initial mitotic spindle pole body separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of exit from mitosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septation initiation signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in outer plaque of mitotic spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer plaque of mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nud1p
    NP_015018.3
    • Mitotic exit network (MEN) scaffold protein; core component of the SPB outer plaque that functions in astral microtubule organization via Spc72p; scaffold for recruitment of MEN components, such as Cdc15p, Tem1p and the Bfa1p-Bub2p checkpoint complex; phosphorylation by Cdc15p creates a Dbf2p-Mob1p phospho-docking site enabling Cdc15p-dependent complex activation and mitotic exit; acts through the MEN to specify Kar9p-mediated asymmetric SPB inheritance; homologous to mammalian centriolin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      1036834..1039389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183793.3 → NP_015018.3  TPA: Nud1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015018.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W366, P32336, Q08895
      UniProtKB/TrEMBL
      A6ZPK1, N1NXJ9
      Conserved Domains (4) summary
      COG4886
      Location:440 → 662
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:794 → 806
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:522 → 544
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:557 → 784
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32336.2

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