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    ari-1.4 Ariadne domain-containing protein;RBR-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

    Gene ID: 178437, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ari-1.4
    Official Full Name
    Ariadne domain-containing protein;RBR-type E3 ubiquitin transferase
    Primary source
    WormBase:WBGene00013538
    Locus tag
    CELE_Y73F8A.34
    See related
    AllianceGenome:WB:WBGene00013538
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine and nervous system. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ari-1.4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (15524092..15528528, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ARI-1, an RBR family ubiquitin-ligase, functions with UBC-18 to regulate pharyngeal development in C. elegans. Qiu X, et al. Dev Biol, 2006 Mar 15. PMID 16457801
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ariadne domain-containing protein;RBR-type E3 ubiquitin transferase
    NP_001041060.1
    • Confirmed by transcript evidence
    NP_001041061.1
    • Partially confirmed by transcript evidence
    NP_001255868.1
    • Confirmed by transcript evidence
    NP_001255869.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      15524092..15528528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047595.3 → NP_001041060.1  RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NA31
      Conserved Domains (2) summary
      smart00647
      Location:193 → 252
      IBR; In Between Ring fingers
      pfam01485
      Location:273 → 314
      IBR; IBR domain, a half RING-finger domain

    2. NM_001268940.3 → NP_001255869.1  RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3NQB5
      Conserved Domains (2) summary
      smart00647
      Location:13 → 72
      IBR; In Between Ring fingers
      pfam01485
      Location:93 → 134
      IBR; IBR domain, a half RING-finger domain

    3. NM_001268939.3 → NP_001255868.1  RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3NQB4
      Conserved Domains (2) summary
      smart00647
      Location:144 → 203
      IBR; In Between Ring fingers
      pfam01485
      Location:224 → 265
      IBR; IBR domain, a half RING-finger domain

    4. NM_001047596.4 → NP_001041061.1  Ariadne domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041061.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2HQK5
    Nucleotide Protein
    Heading Accession and Version

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