U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lit-1 Serine/threonine kinase NLK [ Caenorhabditis elegans ]

    Gene ID: 176808, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lit-1
    Official Full Name
    Serine/threonine kinase NLK
    Primary source
    WormBase:WBGene00003048
    Locus tag
    CELE_W06F12.1
    See related
    AllianceGenome:WB:WBGene00003048
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables beta-catenin binding activity and protein serine/threonine kinase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; cell fate specification; and polarity specification of proximal/distal axis. Located in cell cortex and nucleus. Part of serine/threonine protein kinase complex. Is expressed in several structures, including E; amphid sheath cell; hermaphrodite gonad; pharynx; and tail hypodermis. Orthologous to human NLK (nemo like kinase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See lit-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    14
    Sequence:
    Chromosome: III; NC_003281.10 (13701993..13724404)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene WD repeat-containing protein dyf-2 Neighboring gene Systemic RNA interference defective protein 2 Neighboring gene Cullin-2 Neighboring gene Peptidyl-prolyl cis-trans isomerase 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Zinc finger protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Developmental biology. The worm keeps turning. Bowerman B. Nature, 1997 Nov 20. PMID 9384368
    2. Identification of C. elegans DAF-12-binding sites, response elements, and target genes. Shostak Y, et al. Genes Dev, 2004 Oct 15. PMID 15489294, Free PMC Article
    3. Meta-Boolean models of asymmetric division patterns in the C. elegans intestinal lineage: Implications for the posterior boundary of intestinal twist. Pettersson S, et al. Worm, 2013 Jan 1. PMID 24058861, Free PMC Article
    4. Binary specification of the embryonic lineage in Caenorhabditis elegans. Kaletta T, et al. Nature, 1997 Nov 20. PMID 9384382
    5. In vivo identification of regulators of cell invasion across basement membranes. Matus DQ, et al. Sci Signal, 2010 May 4. PMID 20442418, Free PMC Article

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our data support a model in which WRM-1, which can undergo homotypic interaction, binds LIT-1 and thereby generates a kinase complex in which LIT-1 molecules are situated in a conformation enabling autophosphorylation.
      Title: β-Catenin-related protein WRM-1 is a multifunctional regulatory subunit of the LIT-1 MAPK complex.
    2. Results suggest that the opposing daf-6 and lit-1 glial pathways act together to control sensory compartment size.
      Title: Opposing activities of LIT-1/NLK and DAF-6/patched-related direct sensory compartment morphogenesis in C. elegans.
    3. SYS-1 and POP-1 nuclear levels are regulated in opposite directions; the C terminus of POP-1 is essential for LIT-1 phosphorylation and is specifically bound by the diverged beta-catenin WRM-1
      Title: Distinct and mutually inhibitory binding by two divergent β-catenins coordinates TCF levels and activity in C. elegans.
    4. Overexpressing lit-1 causes heterochronic defects opposite to those in lit-1(lf) mutants. LIT-1 exhibits a periodic expression pattern in seam cells within each larval stage
      Title: Wnt signaling controls temporal identities of seam cells in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in asymmetric protein localization involved in cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endodermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polarity specification of proximal/distal axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of serine/threonine protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Serine/threonine kinase NLK
    NP_001022805.1
    • Confirmed by transcript evidence
    NP_001022806.1
    • Confirmed by transcript evidence
    NP_001022807.1
    • Confirmed by transcript evidence
    NP_001022808.1
    • Confirmed by transcript evidence
    NP_001367102.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13701993..13724404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027637.6 → NP_001022808.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022808.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U9Y8
      Conserved Domains (2) summary
      cd07853
      Location:206 → 583
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
      smart00220
      Location:211 → 498
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    2. NM_001027634.3 → NP_001022805.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022805.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62395, Q69YW9, Q8WQB7, Q9U343, Q9U9Y8, Q9UA07, Q9Y198
      Conserved Domains (2) summary
      cd07853
      Location:239 → 616
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
      smart00220
      Location:244 → 531
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    3. NM_001027635.6 → NP_001022806.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022806.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U9Y8
      Conserved Domains (2) summary
      cd07853
      Location:67 → 444
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
      smart00220
      Location:72 → 359
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    4. NM_001379989.1 → NP_001367102.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd07853
      Location:59 → 436
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase

    5. NM_001027636.4 → NP_001022807.1  Serine/threonine kinase NLK [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022807.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U9Y8
      Conserved Domains (2) summary
      cd07853
      Location:42 → 419
      STKc_NLK; Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase
      smart00220
      Location:47 → 334
      S_TKc; Serine/Threonine protein kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U9Y8.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous