mix-1 Mitotic chromosome and X-chromosome-associated protein mix-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mix-1
Official Full Name: Mitotic chromosome and X-chromosome-associated protein mix-1
Primary source: WormBase:WBGene00003367
Locus tag: CELE_M106.1
See related: AllianceGenome:WB:WBGene00003367
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable chromatin binding activity. Involved in several processes, including dosage compensation by hypoactivation of X chromosome; mitotic chromosome condensation; and positive regulation of nematode male tail tip morphogenesis. Located in chromosome, centromeric region and condensed chromosome. Part of dosage compensation complex. Is expressed in AB. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human SMC2 (structural maintenance of chromosomes 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mix-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 15

Sequence:: Chromosome: II; NC_003280.10 (10824246..10841424)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

VM106R.1 (e-PCR)
- UniSTS:317215

R06F6.10 (e-PCR)
- UniSTS:307842

M106.1 (e-PCR)
- UniSTS:311990

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
involved_in dosage compensation by hypoactivation of X chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in condensed chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dosage compensation complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mitotic chromosome and X-chromosome-associated protein mix-1

NP_496331.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10824246..10841424

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063930.8 → NP_496331.1 Mitotic chromosome and X-chromosome-associated protein mix-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496331.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09591

Conserved Domains (5) summary

cd03273
Location:1 → 157

ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins

COG1196
Location:1 → 1172

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam06470
Location:527 → 654

SMC_hinge; SMC proteins Flexible Hinge Domain

pfam07851
Location:765 → 854

TMPIT; TMPIT-like protein

cl21455
Location:1086 → 1184

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases