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    • Showing Current items.

    pbs-7 Proteasome subunit beta [ Caenorhabditis elegans ]

    Gene ID: 172674, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pbs-7
    Official Full Name
    Proteasome subunit beta
    Primary source
    WormBase:WBGene00003953
    Locus tag
    CELE_F39H11.5
    See related
    AllianceGenome:WB:WBGene00003953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 3. Orthologous to human PSMB4 (proteasome 20S subunit beta 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pbs-7 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (8695205..8696301, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Small ribosomal subunit protein uS15m Neighboring gene MBD domain-containing protein;Pre-mRNA-splicing factor SLU7;Pre-mRNA-splicing factor SYF2 Neighboring gene putative ATP synthase subunit g 1, mitochondrial Neighboring gene Craniofacial development protein 1 Neighboring gene TATA box-binding protein-like 1 Neighboring gene Cyclin-dependent kinase 8 Neighboring gene Collagen alpha-1(XVIII) chain;Endostatin domain-containing protein;Fibronectin type-III domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans. Ferguson AA, et al. Mol Cell Biol, 2010 Jun. PMID 20351174, Free PMC Article
    2. Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans. Sonneville R, et al. Development, 2004 Aug. PMID 15215208
    3. Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response. Choe KP, et al. Am J Physiol Cell Physiol, 2008 Dec. PMID 18829898, Free PMC Article
    4. Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans. Kahn NW, et al. Biochem J, 2008 Jan 1. PMID 17714076
    5. H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Wang S, et al. Nat Struct Mol Biol, 2020 Dec. PMID 33046905

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Proteasome subunit beta
    NP_492354.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8695205..8696301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059953.6 → NP_492354.1  Proteasome subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492354.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P90868
      Conserved Domains (2) summary
      COG0638
      Location:16 → 221
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03760
      Location:16 → 218
      proteasome_beta_type_4; proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    Nucleotide Protein
    Heading Accession and Version

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