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    haf-6 ABC transporter ATP-binding protein;ATP-binding cassette sub-family B member 8, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 171694, updated on 9-Dec-2024

    Summary

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    Official Symbol
    haf-6
    Official Full Name
    ABC transporter ATP-binding protein;ATP-binding cassette sub-family B member 8, mitochondrial
    Primary source
    WormBase:WBGene00001816
    Locus tag
    CELE_Y48G8AL.11
    See related
    AllianceGenome:WB:WBGene00001816
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in perinuclear endoplasmic reticulum. Is expressed in germ line; intestine; and muscle cell. Orthologous to human ABCB8 (ATP binding cassette subfamily B member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See haf-6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (1162880..1175809, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Origin recognition complex subunit 6 Neighboring gene Large ribosomal subunit protein uL22 Neighboring gene Regulator of nonsense transcripts 1 Neighboring gene ncRNA Neighboring gene Doublecortin domain-containing protein;SAM-dependent MTase RsmB/NOP-type domain-containing protein;tRNA (cytosine(34)-C(5))-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ABC transporters and RNAi in Caenorhabditis elegans. Timmons LD. J Bioenerg Biomembr, 2007 Dec. PMID 17994271
    2. The Caenorhabditis elegans rsd-2 and rsd-6 genes are required for chromosome functions during exposure to unfavorable environments. Han W, et al. Genetics, 2008 Apr. PMID 18430922, Free PMC Article
    3. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. Boyd WA, et al. Mutat Res, 2010 Jan 5. PMID 19879883, Free PMC Article
    4. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Sundaram P, et al. Mol Biol Cell, 2006 Aug. PMID 16723499, Free PMC Article
    5. Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7. Sundaram P, et al. Genetics, 2008 Feb. PMID 18245353, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore-dependent iron import into cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ABC transporter ATP-binding protein;ATP-binding cassette sub-family B member 8, mitochondrial
    NP_001293230.1
    • Confirmed by transcript evidence
    NP_001293231.1
    • Confirmed by transcript evidence
    NP_490828.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1162880..1175809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058427.7 → NP_490828.3  ATP-binding cassette sub-family B member 8, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490828.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL17
      Conserved Domains (3) summary
      cd03249
      Location:425 → 663
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      COG1132
      Location:87 → 663
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      pfam00664
      Location:102 → 378
      ABC_membrane; ABC transporter transmembrane region

    2. NM_001306301.3 → NP_001293230.1  ATP-binding cassette sub-family B member 8, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293230.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CKC7
      Conserved Domains (1) summary
      COG1132
      Location:3 → 512
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]

    3. NM_001306302.3 → NP_001293231.1  ABC transporter ATP-binding protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293231.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLQ7
      Conserved Domains (1) summary
      cl38936
      Location:2 → 62
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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