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    swsn-1 SANT domain-containing protein;SWI/SNF complex subunit SMARCC2;SWIRM-assoc_1 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180324, updated on 9-Dec-2024

    Summary

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    Official Symbol
    swsn-1
    Official Full Name
    SANT domain-containing protein;SWI/SNF complex subunit SMARCC2;SWIRM-assoc_1 domain-containing protein
    Primary source
    WormBase:WBGene00004203
    Locus tag
    CELE_Y113G7B.23
    See related
    AllianceGenome:WB:WBGene00004203
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables identical protein binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of vulval development; and positive regulation of growth rate. Predicted to be located in nucleus. Predicted to be part of SWI/SNF complex. Is expressed widely. Used to study alcohol use disorder and cancer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 8 and hydrocephalus. Orthologous to human SMARCC1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1) and SMARCC2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See swsn-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (20239182..20249488, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Pept_C1 domain-containing protein Neighboring gene DNA replication complex GINS protein SLD5;DNA replication complex GINS protein SLD5 C-terminal domain-containing protein Neighboring gene Mediator of RNA polymerase II transcription subunit 17 Neighboring gene Protein arginine N-methyltransferase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of chromatin states and gene expression during HSN neuronal maturation is mediated by EOR-1/PLZF, MAU-2/cohesin loader, and SWI/SNF complex. Shinkai Y, et al. Sci Rep, 2018 May 21. PMID 29786685, Free PMC Article
    2. SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol. Mathies LD, et al. BMC Genomics, 2020 Sep 21. PMID 32957927, Free PMC Article
    3. Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function. Lampersberger L, et al. Proc Natl Acad Sci U S A, 2023 Jan 31. PMID 36689659, Free PMC Article
    4. Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan. Bansal A, et al. Longev Healthspan, 2014. PMID 24834345, Free PMC Article
    5. Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans. Sawa H, et al. Mol Cell, 2000 Sep. PMID 11030341

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol.
      Title: SWI/SNF complexes act through CBP-1 histone acetyltransferase to regulate acute functional tolerance to alcohol.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of growth rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SANT domain-containing protein;SWI/SNF complex subunit SMARCC2;SWIRM-assoc_1 domain-containing protein
    NP_001256906.1
    • Confirmed by transcript evidence
    NP_001256907.1
    • Confirmed by transcript evidence
    NP_001256908.1
    • Confirmed by transcript evidence
    NP_001360451.1
    • Confirmed by transcript evidence
    NP_001360453.1
    • Confirmed by transcript evidence
    NP_001368722.1
    • Confirmed by transcript evidence
    NP_001380243.1
    • Confirmed by transcript evidence
    NP_001380244.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20239182..20249488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269977.5 → NP_001256906.1  SWI/SNF complex subunit SMARCC2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256906.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF87
      Conserved Domains (2) summary
      COG5259
      Location:33 → 509
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      pfam16498
      Location:354 → 415
      SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

    2. NM_001392706.1 → NP_001380243.1  SANT domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6P9B9
      Conserved Domains (3) summary
      COG5259
      Location:1 → 239
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      pfam16495
      Location:189 → 264
      SWIRM-assoc_1; SWIRM-associated region 1
      pfam16498
      Location:84 → 145
      SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

    3. NM_001269978.4 → NP_001256907.1  SWI/SNF complex subunit SMARCC2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8ESF3
      Conserved Domains (2) summary
      COG5259
      Location:33 → 509
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      pfam16498
      Location:354 → 415
      SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

    4. NM_001269979.3 → NP_001256908.1  SANT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256908.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8ESF4
      Conserved Domains (2) summary
      COG5259
      Location:2 → 405
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      pfam16498
      Location:250 → 311
      SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

    5. NM_001380878.1 → NP_001368722.1  SANT domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6NNV9
      Conserved Domains (2) summary
      COG5259
      Location:2 → 405
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      pfam16498
      Location:250 → 311
      SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

    6. NM_001373203.2 → NP_001360451.1  SANT domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6NPD2
      Conserved Domains (3) summary
      COG5259
      Location:1 → 239
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      pfam16495
      Location:189 → 264
      SWIRM-assoc_1; SWIRM-associated region 1
      pfam16498
      Location:84 → 145
      SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

    7. NM_001392707.1 → NP_001380244.1  SWIRM-assoc_1 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6MYA1
      Conserved Domains (2) summary
      pfam16495
      Location:116 → 191
      SWIRM-assoc_1; SWIRM-associated region 1
      pfam16498
      Location:11 → 72
      SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

    8. NM_001373205.2 → NP_001360453.1  SWIRM-assoc_1 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6N6K6
      Conserved Domains (2) summary
      pfam16495
      Location:116 → 191
      SWIRM-assoc_1; SWIRM-associated region 1
      pfam16498
      Location:11 → 72
      SWIRM-assoc_3; SWIRM-associated domain at the C-terminal
    Nucleotide Protein
    Heading Accession and Version

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