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    sms-1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 [ Caenorhabditis elegans ]

    Gene ID: 178072, updated on 4-Jan-2025

    Summary

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    Official Symbol
    sms-1
    Official Full Name
    Phosphatidylcholine:ceramide cholinephosphotransferase 1
    Primary source
    WormBase:WBGene00004892
    Locus tag
    CELE_H21P03.3
    See related
    AllianceGenome:WB:WBGene00004892
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Is expressed in several structures, including body wall musculature; pharyngeal cell; rectal muscle; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in calvarial doughnut lesions with bone fragility. Orthologous to several human genes including SGMS2 (sphingomyelin synthase 2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See sms-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (11482662..11498174, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene HTH cro/C1-type domain-containing protein Neighboring gene Non-structural maintenance of chromosomes element 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BPTI/Kunitz inhibitor domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Clozapine Modulates Glucosylceramide, Clears Aggregated Proteins, and Enhances ATG8/LC3 in Caenorhabditis elegans. Hao L, et al. Neuropsychopharmacology, 2017 Mar. PMID 27711049, Free PMC Article
    2. Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism. Meister P, et al. Genome Biol, 2011 Dec 20. PMID 22185090, Free PMC Article
    3. Sphingolipid profiling reveals differential functions of sphingolipid biosynthesis isozymes of Caenorhabditis elegans. Luo H, et al. J Lipid Res, 2024 Jun. PMID 38704027, Free PMC Article
    4. Identification of a family of animal sphingomyelin synthases. Huitema K, et al. EMBO J, 2004 Jan 14. PMID 14685263, Free PMC Article
    5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ceramide cholinephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide cholinephosphotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingomyelin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingomyelin synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingomyelin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingomyelin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phosphatidylcholine:ceramide cholinephosphotransferase 1
    NP_001129861.2
    • Partially confirmed by transcript evidence
    NP_001255559.1
    • Partially confirmed by transcript evidence
    NP_502168.2
    • Partially confirmed by transcript evidence
    NP_502169.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11482662..11498174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069767.6 → NP_502168.2  Phosphatidylcholine:ceramide cholinephosphotransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502168.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3GWD9, H2L2K5, Q9U3D4, Q9XTV2
      Conserved Domains (2) summary
      pfam03247
      Location:17 → 121
      Prothymosin; Prothymosin/parathymosin family
      pfam14360
      Location:327 → 400
      PAP2_C; PAP2 superfamily C-terminal

    2. NM_069768.6 → NP_502169.2  Phosphatidylcholine:ceramide cholinephosphotransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502169.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U3D4
      Conserved Domains (2) summary
      pfam03247
      Location:6 → 81
      Prothymosin; Prothymosin/parathymosin family
      pfam14360
      Location:287 → 360
      PAP2_C; PAP2 superfamily C-terminal

    3. NM_001268630.3 → NP_001255559.1  Phosphatidylcholine:ceramide cholinephosphotransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255559.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L2K5
      Conserved Domains (2) summary
      pfam05793
      Location:1 → 128
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
      pfam14360
      Location:273 → 346
      PAP2_C; PAP2 superfamily C-terminal

    4. NM_001136389.4 → NP_001129861.2  Phosphatidylcholine:ceramide cholinephosphotransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129861.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U3D4
      Conserved Domains (1) summary
      pfam14360
      Location:210 → 283
      PAP2_C; PAP2 superfamily C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U3D4.2

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