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    asps-1 TUG ubiquitin-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179435, updated on 9-Dec-2024

    Summary

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    Official Symbol
    asps-1
    Official Full Name
    TUG ubiquitin-like domain-containing protein
    Primary source
    WormBase:WBGene00007100
    Locus tag
    CELE_B0024.10
    See related
    AllianceGenome:WB:WBGene00007100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in glucose homeostasis and intracellular protein transport. Predicted to be active in cytoplasm; nucleus; and vesicle membrane. Is expressed in head; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in alveolar soft part sarcoma. Orthologous to human ASPSCR1 (ASPSCR1 tether for SLC2A4, UBX domain containing). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See asps-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (10315248..10317394, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Crescerin-like protein che-12 Neighboring gene ncRNA Neighboring gene Receptor-type guanylate cyclase gcy-6 Neighboring gene Thioredoxin;putative thioredoxin-2 Neighboring gene Putative pseudouridine synthase B0024.11 Neighboring gene Glucosamine 6-phosphate N-acetyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. De-Souza EA, et al. J Biol Chem, 2020 Mar 20. PMID 31996377, Free PMC Article
    2. Use of RNAi as a preliminary tool for screening putative receptors of nematicidal toxins from Bacillus thuringiensis. García-Montelongo M, et al. Arch Microbiol, 2021 May. PMID 33432376
    3. An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans. Meissner B, et al. PLoS Genet, 2009 Jun. PMID 19557190, Free PMC Article
    4. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TUG ubiquitin-like domain-containing protein
    NP_505652.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10315248..10317394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073251.6 → NP_505652.2  TUG ubiquitin-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505652.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17425
      Conserved Domains (3) summary
      cd16105
      Location:4 → 74
      Ubl_ASPSCR1_like; Ubiquitin-like (Ubl) domain found at the N-terminus of mammalian ASPSCR1 (alveolar soft part sarcoma chromosomal region candidate gene 1 protein), Saccharomyces cerevisie Ubx4p, and similar proteins
      cd17075
      Location:81 → 163
      UBX1_UBXN9; Ubiquitin regulatory domain X (UBX) 1 found in UBX domain protein 9 (UBXN9, UBXD9, or ASPSCR1) and similar proteins
      pfam17380
      Location:170 → 407
      DUF5401; Family of unknown function (DUF5401)
    Nucleotide Protein
    Heading Accession and Version

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