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    Y74C10AL.2 Transmembrane protein 50A [ Caenorhabditis elegans ]

    Gene ID: 171806, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y74C10AL.2
    Official Full Name
    Transmembrane protein 50A
    Primary source
    WormBase:WBGene00022280
    Locus tag
    CELE_Y74C10AL.2
    See related
    AllianceGenome:WB:WBGene00022280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway. Predicted to be located in membrane. Orthologous to human TMEM50A (transmembrane protein 50A) and TMEM50B (transmembrane protein 50B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y74C10AL.2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (2468793..2471935, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Innexin-19 Neighboring gene ABC transmembrane type-1 domain-containing protein;Iron-sulfur clusters transporter ABCB7, mitochondrial Neighboring gene Conserved secreted protein Neighboring gene Eukaryotic translation initiation factor 3 subunit I;Serine-threonine kinase receptor-associated protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transmembrane protein 50A
    NP_490985.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2468793..2471935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058584.9 → NP_490985.1  Transmembrane protein 50A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490985.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N2X7
      Conserved Domains (1) summary
      pfam05255
      Location:5 → 156
      UPF0220; uncharacterized protein family (UPF0220)
    Nucleotide Protein
    Heading Accession and Version

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