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    ctbp-1 C-terminal-binding protein 1 [ Caenorhabditis elegans ]

    Gene ID: 180853, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ctbp-1
    Official Full Name
    C-terminal-binding protein 1
    Primary source
    WormBase:WBGene00006424
    Locus tag
    CELE_F49E10.5
    See related
    AllianceGenome:WB:WBGene00006424
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in hypodermis and nervous system. Used to study alcohol use disorder. Orthologous to human CTBP1 (C-terminal binding protein 1) and CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ctbp-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (5862708..5873347)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mitochondria-eating protein C-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Solution structure of the THAP domain from Caenorhabditis elegans C-terminal binding protein (CtBP). Liew CK, et al. J Mol Biol, 2007 Feb 16. PMID 17174978
    2. The C-terminal binding protein (CTBP-1) regulates dorsal SMD axonal morphology in Caenorhabditis elegans. Reid A, et al. Neuroscience, 2015 Dec 17. PMID 26480814
    3. The transcriptional repressor CTBP-1 functions in the nervous system of Caenorhabditis elegans to regulate lifespan. Reid A, et al. Exp Gerontol, 2014 Dec. PMID 25456848
    4. The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span. Chen S, et al. Proc Natl Acad Sci U S A, 2009 Feb 3. PMID 19164523, Free PMC Article
    5. The Caenorhabditis elegans protein CTBP-1 defines a new group of THAP domain-containing CtBP corepressors. Nicholas HR, et al. J Mol Biol, 2008 Jan 4. PMID 18005989

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity in Caenorhabditis elegans.
      Title: The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity in Caenorhabditis elegans.
    2. Results demonstrate a role for CTBP-1 in exploration behavior and the regulation of dorsal SMD axonal morphology in C. elegans
      Title: The C-terminal binding protein (CTBP-1) regulates dorsal SMD axonal morphology in Caenorhabditis elegans.
    3. data confirm that CTBP-1 is involved in the regulation of lips-7 transcription but suggest that it may perform additional roles in the nervous system that contribute to the regulation of longevity
      Title: The transcriptional repressor CTBP-1 functions in the nervous system of Caenorhabditis elegans to regulate lifespan.
    4. data suggest that CTBP-1 controls life span probably through the regulation of lipid metabolism
      Title: The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-terminal-binding protein 1
    NP_001257030.1
    • Confirmed by transcript evidence
    NP_001257031.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5862708..5873347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270101.4 → NP_001257030.1  C-terminal-binding protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257030.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H8W3Z5, Q20595, Q20596
      Conserved Domains (3) summary
      COG0111
      Location:206 → 507
      SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
      cd05299
      Location:179 → 498
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
      pfam05485
      Location:4 → 62
      THAP; THAP domain

    2. NM_001270102.3 → NP_001257031.1  C-terminal-binding protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257031.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20595
      Conserved Domains (2) summary
      COG0111
      Location:85 → 386
      SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
      cd05299
      Location:58 → 377
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20595.3

    Gene LinkOut

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