ags-3 Activator of G protein signaling;TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 28 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ags-3
Official Full Name: Activator of G protein signaling;TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 28
Primary source: WormBase:WBGene00000092
Locus tag: CELE_F32A6.4
See related: AllianceGenome:WB:WBGene00000092
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables G-protein alpha-subunit binding activity. Involved in regulation of feeding behavior. Located in membrane. Is expressed in several structures, including hermaphrodite gonad; intestine; muscle cell; nervous system; and pharynx. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Orthologous to human GPSM1 (G protein signaling modulator 1) and GPSM2 (G protein signaling modulator 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ags-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 16

Sequence:: Chromosome: X; NC_003284.9 (5289728..5303600, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A biological role for AGS-3 is identified in response to food deprivation that indicates the mechanism for activation of Galpha(o) signaling in vivo.
Title: AGS-3 alters Caenorhabditis elegans behavior after food deprivation via RIC-8 activation of the neural G protein G αo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F32A6.4 (e-PCR)
- UniSTS:320290

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables GDP-dissociation inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GDP-dissociation inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables GTPase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Activator of G protein signaling;TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 28

NP_001309689.1

Confirmed by transcript evidence

NP_001309690.1

Confirmed by transcript evidence

NP_001309692.1

Product from WormBase gene class ags;
Confirmed by transcript evidence

NP_001370955.1

Product from WormBase gene class ags;
Confirmed by transcript evidence

NP_741787.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

5289728..5303600 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171684.6 → NP_741787.1 Tetratricopeptide repeat protein 28 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741787.1

Status: REVIEWED

UniProtKB/TrEMBL

Q19955

Conserved Domains (5) summary

smart00390
Location:511 → 533

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

sd00006
Location:186 → 213

TPR; TPR repeat [structural motif]

pfam02188
Location:417 → 437

GoLoco; GoLoco motif

pfam13414
Location:7 → 65

TPR_11; TPR repeat

pfam13424
Location:182 → 255

TPR_12; Tetratricopeptide repeat
NM_001383577.1 → NP_001370955.1 Activator of G protein signaling [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MBC1

Conserved Domains (1) summary

smart00390
Location:90 → 112

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
NM_001322618.4 → NP_001309689.1 TPR_REGION domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MD77

Conserved Domains (4) summary

smart00390
Location:288 → 310

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

sd00006
Location:3 → 30

TPR; TPR repeat [structural motif]

pfam02188
Location:194 → 214

GoLoco; GoLoco motif

pfam13424
Location:3 → 74

TPR_12; Tetratricopeptide repeat
NM_001322619.4 → NP_001309690.1 TPR_REGION domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MBW5, Q86RT4

Conserved Domains (2) summary

smart00390
Location:245 → 267

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

pfam02188
Location:151 → 171

GoLoco; GoLoco motif
NM_001322621.4 → NP_001309692.1 Activator of G protein signaling [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MBA1

Conserved Domains (1) summary

smart00390
Location:33 → 55

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases