U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mtm-9 Myotubularin-related protein 9 [ Caenorhabditis elegans ]

    Gene ID: 178790, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mtm-9
    Official Full Name
    Myotubularin-related protein 9
    Primary source
    WormBase:WBGene00003479
    Locus tag
    CELE_Y39H10A.3
    See related
    AllianceGenome:WB:WBGene00003479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables phosphatase binding activity. Involved in pinocytosis and regulation of cell migration. Located in cytosol and plasma membrane. Is expressed in several structures, including coelomocyte; epithelial cell; intestine; neurons; and vulva. Used to study centronuclear myopathy. Orthologous to human MTMR9 (myotubularin related protein 9). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See mtm-9 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (3743576..3749403)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Fibronectin type-III domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene CTLH domain-containing protein;WD_REPEATS_REGION domain-containing protein Neighboring gene Serine/threonine-protein kinase chk-1 Neighboring gene ncRNA Neighboring gene Acyltransferase 3 domain-containing protein;Nose resistant-to-fluoxetine protein N-terminal domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans. Dang H, et al. Mol Biol Cell, 2004 Jan. PMID 14565969, Free PMC Article
    2. MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans. Ericson VR, et al. PLoS One, 2014. PMID 25479419, Free PMC Article
    3. Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans. Xue Y, et al. J Biol Chem, 2003 Sep 5. PMID 12788949
    4. Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis. Maekawa M, et al. Proc Natl Acad Sci U S A, 2014 Mar 18. PMID 24591580, Free PMC Article
    5. Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells. Silhankova M, et al. EMBO J, 2010 Dec 15. PMID 21076391, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables phosphatidylinositol-3-phosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pinocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Myotubularin-related protein 9
    NP_504038.1
    • Confirmed by transcript evidence
    NP_872167.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      3743576..3749403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_182367.6 → NP_872167.2  Myotubularin-related protein 9 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872167.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q965W9
      Conserved Domains (2) summary
      pfam06602
      Location:72 → 411
      Myotub-related; Myotubularin-like phosphatase domain
      cl17171
      Location:1 → 64
      PH-like; Pleckstrin homology-like domain

    2. NM_071637.7 → NP_504038.1  Myotubularin-related protein 9 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504038.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6F3C7, Q965W9
      Conserved Domains (2) summary
      cd13211
      Location:1 → 108
      PH-GRAM_MTMR9; Myotubularian (MTM) related 9 protein (MTMR9) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam06602
      Location:120 → 459
      Myotub-related; Myotubularin-like phosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q965W9.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous