plk-1 Serine/threonine-protein kinase plk-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: plk-1
Official Full Name: Serine/threonine-protein kinase plk-1
Primary source: WormBase:WBGene00004042
Locus tag: CELE_C14B9.4
See related: AllianceGenome:WB:WBGene00004042
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including meiotic nuclear division; microtubule cytoskeleton organization; and positive regulation of nematode male tail tip morphogenesis. Located in several cellular components, including condensed chromosome; microtubule cytoskeleton; and nucleus. Is expressed in embryonic cell; germ line; and oocyte. Human ortholog(s) of this gene implicated in urinary bladder cancer. Orthologous to human PLK1 (polo like kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See plk-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 6

Sequence:: Chromosome: III; NC_003281.10 (8101348..8104069)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength.
Title: Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength.
Loss of the mitochondrial protein SPD-3 elevates PLK-1 levels and dysregulates mitotic events.
Title: Loss of the mitochondrial protein SPD-3 elevates PLK-1 levels and dysregulates mitotic events.
Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos.
Title: Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos.
BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses.
Title: BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses.
BUB-1 and CENP-C recruit PLK-1 to control chromosome alignment and segregation during meiosis I in C. elegans oocytes.
Title: BUB-1 and CENP-C recruit PLK-1 to control chromosome alignment and segregation during meiosis I in C. elegans oocytes.
Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome.
Title: Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome.
PLK-1 promotes the merger of the parental genome into a single nucleus by triggering lamina disassembly.
Title: PLK-1 promotes the merger of the parental genome into a single nucleus by triggering lamina disassembly.
C. elegans pronuclei fuse after fertilization through a novel membrane structure.
Title: C. elegans pronuclei fuse after fertilization through a novel membrane structure.
mitotic kinase PLK-1 affects cell polarity via the enrichment in somatic AB cells, which limits the cortical localization of the dynein-binding NuMA orthologue LIN-5
Title: Cell polarity-dependent centrosome separation in the C. elegans embryo.
The polo-like kinase PLK-1 mediates the repulsive coupling between MEX-5 and POS-1 by increasing the mobility of POS-1 in the anterior.
Title: Polo-like Kinase Couples Cytoplasmic Protein Gradients in the C. elegans Zygote.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C14B9.4 (e-PCR)
- UniSTS:308551

K06H7.1 (e-PCR)
- UniSTS:311438

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female meiosis II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic nuclear membrane disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic nuclear membrane disassembly	TAS Traceable Author Statement more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polar body extrusion after meiotic divisions	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in midbody	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Serine/threonine-protein kinase plk-1

NP_001021173.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8101348..8104069

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026002.6 → NP_001021173.1 Serine/threonine-protein kinase plk-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021173.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61662, O76763, P34331

Conserved Domains (4) summary

smart00220
Location:38 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13117
Location:513 → 594

POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd13118
Location:409 → 499

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd14099
Location:36 → 289

STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases