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    K12H4.7 Putative serine protease K12H4.7 [ Caenorhabditis elegans ]

    Gene ID: 176136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    K12H4.7
    Official Full Name
    Putative serine protease K12H4.7
    Primary source
    WormBase:WBGene00019682
    Locus tag
    CELE_K12H4.7
    See related
    AllianceGenome:WB:WBGene00019682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dipeptidyl-peptidase activity. Involved in innate immune response. Is expressed in intestine. Orthologous to human PRSS16 (serine protease 16). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See K12H4.7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (8048450..8051081, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Signal peptidase complex subunit 3 Neighboring gene Ribosome biogenesis protein BRX1 homolog Neighboring gene Mitochondrial Assembly of ribosomal Large Subunit Neighboring gene ncRNA Neighboring gene Homeobox protein prospero homolog 1 Neighboring gene ncRNA Neighboring gene tRNA-Pro

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of C. elegans Y-box-binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes. Arnold A, et al. Nucleic Acids Res, 2014 Dec 1. PMID 25378320, Free PMC Article
    2. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Zhang C, et al. Curr Biol, 2012 May 22. PMID 22542102, Free PMC Article
    3. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
    4. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article
    5. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type exopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Putative serine protease K12H4.7
    NP_498758.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8048450..8051081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066357.6 → NP_498758.2  Putative serine protease K12H4.7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498758.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34528, Q95QC8
      Conserved Domains (1) summary
      pfam05577
      Location:65 → 499
      Peptidase_S28; Serine carboxypeptidase S28
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34528.2

    Gene LinkOut

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