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    ergi-1 Endoplasmic reticulum-Golgi intermediate compartment protein 1 [ Caenorhabditis elegans ]

    Gene ID: 180517, updated on 9-Dec-2024

    Summary

    Official Symbol
    ergi-1
    Official Full Name
    Endoplasmic reticulum-Golgi intermediate compartment protein 1
    Primary source
    WormBase:WBGene00022416
    Locus tag
    CELE_Y102A11A.6
    See related
    AllianceGenome:WB:WBGene00022416
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum membrane. Is expressed in nervous system and pharynx. Human ortholog(s) of this gene implicated in neurogenic-type arthrogryposis multiplex congenita-2. Orthologous to human ERGIC1 (endoplasmic reticulum-golgi intermediate compartment 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ergi-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (2031868..2035272, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Protein unc-13 homolog A Neighboring gene Chromatin-remodeling ATPase INO80 Neighboring gene MliC domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CX domain-containing protein

    General gene information

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Endoplasmic reticulum-Golgi intermediate compartment protein 1
    NP_508375.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2031868..2035272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075974.6NP_508375.1  Endoplasmic reticulum-Golgi intermediate compartment protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508375.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95XJ9
      Conserved Domains (2) summary
      pfam07970
      Location:110267
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:495
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)