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    glb-5 Globin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 182776, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glb-5
    Official Full Name
    Globin domain-containing protein
    Primary source
    WormBase:WBGene00015964
    Locus tag
    CELE_C18C4.1
    See related
    AllianceGenome:WB:WBGene00015964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables oxygen sensor activity. Involved in detection of oxygen. Is expressed in PQR; head neurons; intestine; pharynx; and somatic nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glb-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (5558890..5564263)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene GRIP domain-containing protein;Golgin-84 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Globin-like protein 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of sensory information processing by a neuroglobin in Caenorhabditis elegans. Oda S, et al. Proc Natl Acad Sci U S A, 2017 Jun 6. PMID 28536200, Free PMC Article
    2. Environmental Programming of Adult Foraging Behavior in C. elegans. Pradhan S, et al. Curr Biol, 2019 Sep 9. PMID 31422888
    3. Characterization of gene expression associated with the adaptation of the nematode C. elegans to hypoxia and reoxygenation stress reveals an unexpected function of the neuroglobin GLB-5 in innate immunity. Zuckerman B, et al. Free Radic Biol Med, 2017 Jul. PMID 28495447
    4. The laboratory domestication of Caenorhabditis elegans. Sterken MG, et al. Trends Genet, 2015 May. PMID 25804345, Free PMC Article
    5. Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory behaviors. McGrath PT, et al. Neuron, 2009 Mar 12. PMID 19285466, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A computational model of aerotaxis suggests the relationship between GLB-5-modulated sensory receptor neuron responses and reversal behavior is sufficient to broaden O2 preference.
      Title: Modulation of sensory information processing by a neuroglobin in Caenorhabditis elegans.
    2. this study reveals an unexpected function of the neuroglobin GLB-5 in innate immunity and adaptation of the nematode C. elegans to hypoxia and reoxygenation stress
      Title: Characterization of gene expression associated with the adaptation of the nematode C. elegans to hypoxia and reoxygenation stress reveals an unexpected function of the neuroglobin GLB-5 in innate immunity.
    3. GLB-5 and the soluble guanylate cyclases operate in close proximity to regulate O2 responses in dendrites.
      Title: GLOBIN-5-dependent O2 responses are regulated by PDL-1/PrBP that targets prenylated soluble guanylate cyclases to dendritic endings.
    4. effect of the glb-5 gene on oxygen sensing and foraging is modified by the naturally variable neuropeptide receptor npr-1
      Title: Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen carrier activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen carrier activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen sensor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of oxygen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oxygen transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxygen transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Globin domain-containing protein
    NP_001294744.1
    • Confirmed by transcript evidence
    NP_001343626.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5558890..5564263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356646.3 → NP_001343626.1  Globin domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3RMS5, M1ZMJ2
      Conserved Domains (1) summary
      cd01040
      Location:84 → 227
      Mb-like; myoglobin-like; M family globin domain

    2. NM_001307815.4 → NP_001294744.1  Globin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3RMS5, M1ZMJ2
      Conserved Domains (1) summary
      cd01040
      Location:84 → 227
      Mb-like; myoglobin-like; M family globin domain
    Nucleotide Protein
    Heading Accession and Version

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