pdhk-2 putative [pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pdhk-2
Official Full Name: putative [pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial
Primary source: WormBase:WBGene00022719
Locus tag: CELE_ZK370.5
See related: AllianceGenome:WB:WBGene00022719
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in regulation of acetyl-CoA biosynthetic process from pyruvate and regulation of glucose metabolic process. Located in perinuclear region of cytoplasm. Is expressed in head neurons; intestine; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 6. Orthologous to several human genes including PDK1 (pyruvate dehydrogenase kinase 1) and PDK4 (pyruvate dehydrogenase kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pdhk-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (8737686..8741412, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDHK-2 serves as a molecular bridge, connecting fat metabolism and survival under nutritionally adverse conditions in C. elegans
Title: PDHK-2 deficiency is associated with attenuation of lipase-mediated fat consumption for the increased survival of Caenorhabditis elegans dauers.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK370.5 (e-PCR)
- UniSTS:319829

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: putative [pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial

NP_498928.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8737686..8741412 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066527.6 → NP_498928.1 putative [pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498928.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q02332

Conserved Domains (3) summary

smart00387
Location:238 → 357

HATPase_c; Histidine kinase-like ATPases

COG0642
Location:226 → 365

BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]

pfam10436
Location:30 → 188

BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase