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    rnf-126 RING-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

    Gene ID: 171875, updated on 4-Jan-2025

    Summary

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    Official Symbol
    rnf-126
    Official Full Name
    RING-type E3 ubiquitin transferase
    Primary source
    WormBase:WBGene00021842
    Locus tag
    CELE_Y54E10BR.3
    See related
    AllianceGenome:WB:WBGene00021842
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Orthologous to human RNF115 (ring finger protein 115) and RNF126 (ring finger protein 126). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See rnf-126 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (3021651..3028396)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Dual specificity mitogen-activated protein kinase kinase mek-2 Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene RNA-binding protein NOB1 Neighboring gene Signal peptidase complex catalytic subunit SEC11 Neighboring gene ADP-ribosylation factor-related protein 1 Neighboring gene DNA-directed RNA polymerase II subunit RPB7 Neighboring gene Transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
    2. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING-type E3 ubiquitin transferase
    NP_491091.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3021651..3028396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058690.6 → NP_491091.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491091.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N3D1
      Conserved Domains (3) summary
      cd00162
      Location:238 → 278
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      pfam14369
      Location:3 → 33
      zinc_ribbon_9; zinc-ribbon
      cl17238
      Location:237 → 279
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version

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