mys-1 Histone acetyltransferase Tip60 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mys-1
Official Full Name: Histone acetyltransferase Tip60 homolog
Primary source: WormBase:WBGene00007029
Locus tag: CELE_VC5.4
See related: AllianceGenome:WB:WBGene00007029
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable chromatin binding activity; histone H4K16 acetyltransferase activity; and transcription coregulator activity. Involved in several processes, including negative regulation of DNA-templated transcription; negative regulation of cell fate specification; and protein localization to chromatin. Predicted to be located in chromatin. Predicted to be part of NuA4 histone acetyltransferase complex. Predicted to be active in nucleus. Used to study obesity. Orthologous to human KAT5 (lysine acetyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mys-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (7081545..7084662, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HTZ-1 and MYS-1 repress ceh-22 when UTX-1 removes its silencing mark, H3K27 methylation on the ceh-22 locus, thereby maintaining the fates of SGCs.
Title: HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans.
a histone modifying complex, composed of the LSY-12 MYST-type histone acetyltransferase, the ING-family protein LSY-13, and PHD/bromodomain protein LIN-49, is required to initiate and actively maintain lateralized gene expression in the gustatory system
Title: Maintenance of neuronal laterality in Caenorhabditis elegans through MYST histone acetyltransferase complex components LSY-12, LSY-13 and LIN-49.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

VC5.4 (e-PCR)
- UniSTS:318864

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide-lysine-N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to chromatin	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Histone acetyltransferase Tip60 homolog

NP_504796.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

7081545..7084662 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072395.5 → NP_504796.1 Histone acetyltransferase Tip60 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504796.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9TYU5

Conserved Domains (3) summary

COG5027
Location:45 → 444

SAS2; Histone acetyltransferase (MYST family) [Chromatin structure and dynamics]

pfam11717
Location:30 → 86

Tudor-knot; RNA binding activity-knot of a chromodomain

cl17182
Location:168 → 446

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate