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    atg-10 Ubiquitin-like-conjugating enzyme ATG10 [ Caenorhabditis elegans ]

    Gene ID: 183959, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atg-10
    Official Full Name
    Ubiquitin-like-conjugating enzyme ATG10
    Primary source
    WormBase:WBGene00008427
    Locus tag
    CELE_D2085.2
    See related
    AllianceGenome:WB:WBGene00008427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin-like protein transferase activity. Involved in autophagy. Predicted to be active in phagophore assembly site. Orthologous to human ATG10 (autophagy related 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See atg-10 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (8659135..8659800)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Integrase Neighboring gene Glutamine-dependent carbamoyl-phosphate synthase Neighboring gene Translation initiation factor eIF2B subunit epsilon Neighboring gene PIGA GPI anchor biosynthesis domain-containing protein Neighboring gene E3 ubiquitin-protein ligase etc-1 Neighboring gene Ral GTPase-activating protein subunit alpha/beta N-terminal domain-containing protein;Rap-GAP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autophagy in C. elegans. Meléndez A, et al. WormBook, 2009 Aug 24. PMID 19705512
    2. Nuclear hormone receptor NHR-49 acts in parallel with HIF-1 to promote hypoxia adaptation in Caenorhabditis elegans. Doering KRS, et al. Elife, 2022 Mar 14. PMID 35285794, Free PMC Article
    3. Genetic impairment of autophagy intensifies expanded polyglutamine toxicity in Caenorhabditis elegans. Khan LA, et al. Biochem Biophys Res Commun, 2008 Apr 11. PMID 18261464
    4. Autophagy during ageing - from Dr Jekyll to Mr Hyde. Wilhelm T, et al. FEBS J, 2018 Jul. PMID 29630766
    5. Autophagy Regulation Influences β-Amyloid Toxicity in Transgenic Caenorhabditis elegans. Lin H, et al. Front Aging Neurosci, 2022. PMID 35645788, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-like-conjugating enzyme ATG10
    NP_495839.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8659135..8659800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063438.3 → NP_495839.2  Ubiquitin-like-conjugating enzyme ATG10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495839.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18991
      Conserved Domains (1) summary
      pfam03987
      Location:54 → 122
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
    Nucleotide Protein
    Heading Accession and Version

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