coel-1 Tubulin-specific chaperone cofactor E-like protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: coel-1
Official Full Name: Tubulin-specific chaperone cofactor E-like protein
Primary source: WormBase:WBGene00016866
Locus tag: CELE_C52B9.3
See related: AllianceGenome:WB:WBGene00016866
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable alpha-tubulin binding activity. Predicted to be involved in microtubule cytoskeleton organization; post-chaperonin tubulin folding pathway; and tubulin complex assembly. Predicted to be active in cytoplasm. Is expressed in head; tail neurons; and touch receptor neurons. Orthologous to human TBCEL (tubulin folding cofactor E like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See coel-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (4265663..4270554)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our findings reveal a key role for TBCEL/coel-1 in regulating microtubule function during metazoan development and neuronal differentiation.
Title: Identification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C52B9.3 (e-PCR)
- UniSTS:319158

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-chaperonin tubulin folding pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in tubulin complex assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Tubulin-specific chaperone cofactor E-like protein

NP_741764.1

Confirmed by transcript evidence

NP_741765.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4265663..4270554

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171947.7 → NP_741765.1 Tubulin-specific chaperone cofactor E-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741765.1

Status: REVIEWED

Conserved Domains (2) summary

cd00116
Location:40 → 146

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:46 → 64

LRR_1; leucine-rich repeat [structural motif]
NM_171665.6 → NP_741764.1 Tubulin-specific chaperone cofactor E-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741764.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2KYZ5, Q8IFX8

Conserved Domains (1) summary

sd00031
Location:46 → 64

LRR_1; leucine-rich repeat [structural motif]