thoc-2 THO complex subunit 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: thoc-2
Official Full Name: THO complex subunit 2
Primary source: WormBase:WBGene00015813
Locus tag: CELE_C16A3.8
See related: AllianceGenome:WB:WBGene00015813
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in nucleus. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See thoc-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 14

Sequence:: Chromosome: III; NC_003281.10 (6368042..6373904)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

THOC-2 mutants show defective meiosis and an impairment of premeiotic replication as well as DNA-damage accumulation.
Title: R-loops cause replication impairment and genome instability during meiosis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C56G2.15 (e-PCR)
- UniSTS:316452

C16A3.8 (e-PCR)
- UniSTS:308573

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of THO complex	IEA Inferred from Electronic Annotation more info
part_of THO complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of THO complex part of transcription export complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: THO complex subunit 2

NP_498392.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6368042..6373904

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065991.8 → NP_498392.2 THO complex subunit 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498392.2

Status: REVIEWED

UniProtKB/TrEMBL

Q18033

Conserved Domains (5) summary

pfam08208
Location:1192 → 1342

RNA_polI_A34; DNA-directed RNA polymerase I subunit RPA34.5

pfam11262
Location:863 → 1142

Tho2; Transcription factor/nuclear export subunit protein 2

pfam11732
Location:549 → 623

Thoc2; Transcription- and export-related complex subunit

pfam16134
Location:35 → 547

THOC2_N; THO complex subunit 2 N-terminus

pfam16294
Location:1291 → 1354

RSB_motif; RNSP1-SAP18 binding (RSB) motif