pxn-1 Peroxidasin homolog pxn-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pxn-1
Official Full Name: Peroxidasin homolog pxn-1
Primary source: WormBase:WBGene00004256
Locus tag: CELE_ZK994.3
See related: AllianceGenome:WB:WBGene00004256
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable peroxidase activity. Involved in muscle attachment and positive regulation of axon guidance. Located in basement membrane. Is expressed in several structures, including egg-laying apparatus; excretory cell; neurons; somatic nervous system; and spermathecal-uterine valve cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; anterior segment dysgenesis 7; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including PXDN (peroxidasin) and PXDNL (peroxidasin like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pxn-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 22

Sequence:: Chromosome: V; NC_003283.11 (8494889..8502442)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There is a negative relationship between pxn-1 and pxn-2 via pxn-1 regulating pxn-2. Therefore, pxn-1 may function in neuronal development and age-related neuronal maintenance through pxn-2.
Title: pxn-1 and pxn-2 May Interact Negatively during Neuronal Development and Aging in C. elegans.
Results suggest that pxn-1, like other peroxidasins, plays an important role throughout development of Caenorhabditis elegans.
Title: A role for peroxidasin PXN-1 in aspects of C. elegans development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK994.4 (e-PCR)
- UniSTS:318834

ZK994.3 (e-PCR)
- UniSTS:312496

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables lactoperoxidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Peroxidasin homolog pxn-1

NP_505188.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

8494889..8502442

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072787.4 → NP_505188.3 Peroxidasin homolog pxn-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505188.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q1ENI8

Conserved Domains (10) summary

cd09826
Location:757 → 1203

peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins

smart00408
Location:328 → 392

IGc2; Immunoglobulin C-2 Type

smart00410
Location:414 → 496

IG_like; Immunoglobulin like

pfam07679
Location:315 → 400

I-set; Immunoglobulin I-set domain

sd00033
Location:35 → 53

LRR_RI; leucine-rich repeat [structural motif]

pfam01462
Location:23 → 51

LRRNT; Leucine rich repeat N-terminal domain

pfam03098
Location:634 → 1181

An_peroxidase; Animal haem peroxidase

pfam12799
Location:77 → 120

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:52 → 112

LRR_8; Leucine rich repeat

cl11960
Location:420 → 496

Ig; Immunoglobulin domain