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    vsra-1 Piwi domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vsra-1
    Official Full Name
    Piwi domain-containing protein
    Primary source
    WormBase:WBGene00007297
    Locus tag
    CELE_C04F12.1
    See related
    AllianceGenome:WB:WBGene00007297
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA endonuclease activity; miRNA binding activity; and single-stranded RNA binding activity. Involved in IRE1-mediated unfolded protein response. Predicted to be part of RISC complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in germ line; gonad; vulva; and in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vsra-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (9673664..9678557, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene mRNA guanylyltransferase Neighboring gene Piwi domain-containing protein Neighboring gene putative ribosome biogenesis protein RLP24 Neighboring gene tRNA Neighboring gene Death domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An antiviral role for the RNA interference machinery in Caenorhabditis elegans. Schott DH, et al. Proc Natl Acad Sci U S A, 2005 Dec 20. PMID 16339901, Free PMC Article
    2. A small RNA system ensures accurate homologous pairing and unpaired silencing of meiotic chromosomes. Tabara H, et al. EMBO J, 2023 Jun 1. PMID 37078421, Free PMC Article
    3. A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions. Seroussi U, et al. Elife, 2023 Feb 15. PMID 36790166, Free PMC Article
    4. Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Yigit E, et al. Cell, 2006 Nov 17. PMID 17110334
    5. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Grishok A, et al. Cell, 2001 Jul 13. PMID 11461699

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Piwi domain-containing protein
    NP_001417601.1
    • Confirmed by transcript evidence
    NP_492573.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9673664..9678557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060172.6 → NP_492573.1  Piwi domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492573.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XVF1
      Conserved Domains (2) summary
      smart00950
      Location:589 → 902
      Piwi; This domain is found in the protein Piwi and its relatives
      PRK14971
      Location:13 → 231
      PRK14971; DNA polymerase III subunit gamma/tau

    2. NM_001430672.1 → NP_001417601.1  Piwi domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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