U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    dip-2 AMP-dependent synthetase/ligase domain-containing protein;DMAP1-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565539, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    dip-2
    Official Full Name
    AMP-dependent synthetase/ligase domain-containing protein;DMAP1-binding domain-containing protein
    Primary source
    WormBase:WBGene00017885
    Locus tag
    CELE_F28B3.4
    See related
    AllianceGenome:WB:WBGene00017885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Is expressed in hypodermal cell and neurons. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DIP2A (disco interacting protein 2 homolog A); DIP2B (disco interacting protein 2 homolog B); and DIP2C (disco interacting protein 2 homolog C). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See dip-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    18
    Sequence:
    Chromosome: I; NC_003279.8 (4934259..4949353)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Importin N-terminal domain-containing protein Neighboring gene Major Facilitator Superfamily Domain containing homolog Neighboring gene Phospholipid/glycerol acyltransferase domain-containing protein Neighboring gene Chloride channel protein CLC-d Neighboring gene Uncharacterized protein Neighboring gene Structural maintenance of chromosomes protein 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons. Noblett N, et al. J Cell Biol, 2019 Jan 7. PMID 30396999, Free PMC Article
    2. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons.
      Title: DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    AMP-dependent synthetase/ligase domain-containing protein;DMAP1-binding domain-containing protein
    NP_001293298.1
    • Confirmed by transcript evidence
    NP_001293299.1
    • Confirmed by transcript evidence
    NP_001293301.1
    • Confirmed by transcript evidence
    NP_001293302.1
    • Confirmed by transcript evidence
    NP_001293304.1
    • Confirmed by transcript evidence
    NP_001293305.1
    • Confirmed by transcript evidence
    NP_001368484.1
    • Partially confirmed by transcript evidence
    NP_491483.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4934259..4949353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306369.4 → NP_001293298.1  DMAP1-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293298.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AD00
      Conserved Domains (2) summary
      cd05905
      Location:1096 → 1677
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:4 → 114
      DMAP_binding; DMAP1-binding Domain

    2. NM_001306373.4 → NP_001293302.1  DMAP1-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293302.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AE78
      Conserved Domains (2) summary
      cd05905
      Location:1094 → 1675
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:4 → 114
      DMAP_binding; DMAP1-binding Domain

    3. NM_001306375.3 → NP_001293304.1  AMP-dependent synthetase/ligase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293304.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AJH3
      Conserved Domains (1) summary
      cd05905
      Location:1070 → 1651
      Dip2; Disco-interacting protein 2 (Dip2)

    4. NM_001306376.3 → NP_001293305.1  AMP-dependent synthetase/ligase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293305.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AL52
      Conserved Domains (1) summary
      cd05905
      Location:1068 → 1649
      Dip2; Disco-interacting protein 2 (Dip2)

    5. NM_001306372.4 → NP_001293301.1  AMP-dependent synthetase/ligase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293301.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AD24
      Conserved Domains (1) summary
      cd05905
      Location:954 → 1535
      Dip2; Disco-interacting protein 2 (Dip2)

    6. NM_001306370.3 → NP_001293299.1  AMP-dependent synthetase/ligase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293299.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AJG8
      Conserved Domains (1) summary
      cd05905
      Location:956 → 1537
      Dip2; Disco-interacting protein 2 (Dip2)

    7. NM_001379985.1 → NP_001368484.1  AMP-dependent synthetase/ligase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AL47
      Conserved Domains (1) summary
      cd05905
      Location:724 → 1305
      Dip2; Disco-interacting protein 2 (Dip2)

    8. NM_059082.7 → NP_491483.4  AMP-dependent synthetase/ligase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491483.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1RS87
      Conserved Domains (1) summary
      cd05905
      Location:722 → 1303
      Dip2; Disco-interacting protein 2 (Dip2)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools