mec-17 Alpha-tubulin N-acetyltransferase 1;N-acetyltransferase domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mec-17
Official Full Name: Alpha-tubulin N-acetyltransferase 1;N-acetyltransferase domain-containing protein
Primary source: WormBase:WBGene00003178
Locus tag: CELE_F57H12.7
See related: AllianceGenome:WB:WBGene00003178
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables tubulin N-acetyltransferase activity. Involved in mechanoreceptor differentiation and thigmotaxis. Predicted to be located in microtubule. Is expressed in touch receptor neurons. Used to study neurodegenerative disease. Orthologous to human ATAT1 (alpha tubulin acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mec-17 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 5

Sequence:: Chromosome: IV; NC_003282.8 (7983802..7987183, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of MEC-17 affects microtubule dynamics, axonal transport and causes axonal degeneration.
Title: Loss of MEC-17 leads to microtubule instability and axonal degeneration.
MEC-17 allows the production of 15-protofilament microtubules in touch receptor neurons.
Title: Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organization.
Study shows that MEC-17, a protein related to the Gcn5 histone acetyltransferases4 and required for the function of touch receptor neurons in Caenorhabditis elegans.
Title: MEC-17 is an alpha-tubulin acetyltransferase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F57H12.7 (e-PCR)
- UniSTS:313187

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables tubulin N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tubulin N-acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in alpha-tubulin acetylation	IEA Inferred from Electronic Annotation more info
involved_in mechanoreceptor differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron development	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in thigmotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thigmotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in microtubule	IC Inferred by Curator more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Alpha-tubulin N-acetyltransferase 1;N-acetyltransferase domain-containing protein

NP_001368448.1

Confirmed by transcript evidence

NP_501337.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7983802..7987183 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068936.5 → NP_501337.1 Alpha-tubulin N-acetyltransferase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501337.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45100

Conserved Domains (1) summary

pfam05301
Location:67 → 177

Mec-17; Touch receptor neuron protein Mec-17
NM_001380349.1 → NP_001368448.1 N-acetyltransferase domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

W6RR23

Conserved Domains (1) summary

pfam05301
Location:1 → 97

Acetyltransf_16; GNAT acetyltransferase, Mec-17