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    mxl-2 Max-like protein homolog 2 [ Caenorhabditis elegans ]

    Gene ID: 175184, updated on 9-Dec-2024

    Summary

    Official Symbol
    mxl-2
    Official Full Name
    Max-like protein homolog 2
    Primary source
    WormBase:WBGene00003510
    Locus tag
    CELE_F40G9.11
    See related
    AllianceGenome:WB:WBGene00003510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in determination of adult lifespan. Acts upstream of or within negative regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in Takayasu's arteritis. Orthologous to human MLX (MAX dimerization protein MLX). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See mxl-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (186949..188131, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene TransThyretin-Related family domain Neighboring gene pseudo Neighboring gene E2 ubiquitin-conjugating enzyme Neighboring gene Cytochrome c oxidase copper chaperone Neighboring gene ncRNA

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Max-like protein homolog 2
    NP_497173.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      186949..188131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064772.7NP_497173.1  Max-like protein homolog 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497173.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TZ70
      Conserved Domains (1) summary
      cd11404
      Location:47110
      bHLHzip_Mlx_like; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family