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    CAMK2B calcium/calmodulin dependent protein kinase II beta [ Homo sapiens (human) ]

    Gene ID: 816, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CAMK2Bprovided by HGNC
    Official Full Name
    calcium/calmodulin dependent protein kinase II betaprovided by HGNC
    Primary source
    HGNC:HGNC:1461
    See related
    Ensembl:ENSG00000058404 MIM:607707; AllianceGenome:HGNC:1461
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAM2; CAMK2; CAMKB; MRD54; CaMKIIbeta
    Summary
    The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
    Expression
    Biased expression in brain (RPKM 44.0), heart (RPKM 16.4) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CAMK2B in Genome Data Viewer
    Location:
    7p13
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (44217154..44326013, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (44375741..44485432, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44256753..44365193, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375257 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44223563-44224100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44224101-44224636 Neighboring gene glucokinase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18143 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44253740-44254655 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44257065-44257612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44257613-44258158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44260592-44261156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44261157-44261720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44275325-44276208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25933 Neighboring gene YKT6 v-SNARE homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25935 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44289329-44289847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25937 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44301759-44302258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44302657-44303488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44303489-44304320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44307709-44308208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44307207-44307708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44311666-44312166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44322903-44323685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44328206-44328848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44329545-44330046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44333819-44334319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25938 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44348485-44349088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44349089-44349690 Neighboring gene uncharacterized LOC124901621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25939 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44389311-44389811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25940 Neighboring gene NudC domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 3634 Neighboring gene ribosomal protein L32 pseudogene 18 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18144 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:44532074-44532200 Neighboring gene RNA, U6 small nuclear 1097, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clinical exome sequencing of 1000 families with complex immune phenotypes: Toward comprehensive genomic evaluations. Similuk MN, et al. J Allergy Clin Immunol, 2022 Oct. PMID 35753512, Free PMC Article
    2. Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities. Wang P, et al. FEBS Lett, 2000 Jun 16. PMID 10858498
    3. CaMKIIβ in Neuronal Development and Plasticity: An Emerging Candidate in Brain Diseases. Nicole O, et al. Int J Mol Sci, 2020 Oct 1. PMID 33019657, Free PMC Article
    4. A familial case of CAMK2B mutation with variable expressivity. Heiman P, et al. SAGE Open Med Case Rep, 2021. PMID 33796307, Free PMC Article
    5. Alternative splicing generates a CaM kinase IIbeta isoform in myocardium that targets the sarcoplasmic reticulum through a putative alphaKAP and regulates GAPDH. Singh P, et al. Mol Cell Biochem, 2005 Feb. PMID 15792370

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Understanding the pathogenetic mechanisms underlying altered neuronal function associated with CAMK2B mutations.
      Title: Understanding the pathogenetic mechanisms underlying altered neuronal function associated with CAMK2B mutations.
    2. Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.
      Title: Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.
    3. CaMKIIbeta in Neuronal Development and Plasticity: An Emerging Candidate in Brain Diseases.
      Title: CaMKIIβ in Neuronal Development and Plasticity: An Emerging Candidate in Brain Diseases.
    4. CaMKII regulates KCNQ1 at S484 during sustained beta-AR stimulation to inhibit IKs. The ability of CaMKII to inhibit IKs may contribute to arrhythmogenicity during HF.
      Title: Calcium/calmodulin-dependent protein kinase II regulation of I(Ks) during sustained β-adrenergic receptor stimulation.
    5. The importance of CAMK2A and CAMK2B and their auto-phosphorylation in human brain function.
      Title: De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.
    6. TGFbeta elevated the expression of CamK IIbeta and CamK IIdelta, while siRNA silencing of those two subtypes significantly reduced TGFbeta-mediated expression of collagen A1 and fibronectin 1.
      Title: Ca(2+)/calmodulin-dependent protein kinase IIβ and IIδ mediate TGFβ-induced transduction of fibronectin and collagen in human pulmonary fibroblasts.
    7. Due to similarity of structure variations, we suggest that these compounds may have an effect on beta-CaMKII and that sengesterone may have a similar efficacy as the control.
      Title: Possible inhibitor from traditional Chinese medicine for the β form of calcium-dependent protein kinase type II in the treatment of major depressive disorder.
    8. beta-carotene reverses the IL-1beta-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells
      Title: β-carotene reverses the IL-1β-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells.
    9. Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
      Title: Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
    10. Promoter methylations of CAMK2B and ARFGEF1 are novel epigenetic markers identified in breast cancer cell lines.
      Title: Downregulation of ARFGEF1 and CAMK2B by promoter hypermethylation in breast cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual disability, autosomal dominant 54
    MedGen: C4540484 OMIM: 617799 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2023-01-25)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2023-01-25)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
    EBI GWAS Catalog
    Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat induces CAK2B Thr-287 phosphorylation in mature and immature oligodendrocytes in vitro PubMed
    tat HIV-1 Tat activates CAMK2B in both mature and immature oligodendrocytes in vitro PubMed
    tat Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors PubMed
    tat HIV-1 Tat inhibits the activation of CAMKII elicited via LFA-1 in NK cells, providing evidence that Tat inhibits NK cell activation which might contribute to the impairment of natural immunity in HIV-1 infection PubMed
    tat HIV-1 Tat inhibits the activation of CAMKII elicited via beta (3) integrin PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29528

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of synapse maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of calcium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of dendritic spine development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of long-term neuronal synaptic plasticity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of skeletal muscle adaptation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of synapse structural plasticity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of calcium- and calmodulin-dependent protein kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calcium/calmodulin-dependent protein kinase type II subunit beta
    Names
    CaM kinase II beta subunit
    CaM-kinase II beta chain
    caMK-II subunit beta
    proline rich calmodulin-dependent protein kinase
    NP_001211.3
    NP_001280099.1
    NP_742075.1
    NP_742076.1
    NP_742077.1
    NP_742078.1
    NP_742079.1
    NP_742080.1
    NP_742081.1
    XP_005249919.1
    XP_005249921.1
    XP_006715844.1
    XP_006715847.1
    XP_011513849.1
    XP_011513851.1
    XP_011513852.1
    XP_011513853.1
    XP_011513854.1
    XP_011513855.1
    XP_011513856.1
    XP_011513857.1
    XP_011513858.1
    XP_011513859.1
    XP_011513860.1
    XP_011513861.1
    XP_016868149.1
    XP_016868150.1
    XP_016868151.1
    XP_016868153.1
    XP_016868154.1
    XP_024302713.1
    XP_047276836.1
    XP_047276837.1
    XP_047276838.1
    XP_047276839.1
    XP_054215063.1
    XP_054215064.1
    XP_054215065.1
    XP_054215066.1
    XP_054215067.1
    XP_054215068.1
    XP_054215069.1
    XP_054215070.1
    XP_054215071.1
    XP_054215072.1
    XP_054215073.1
    XP_054215074.1
    XP_054215075.1
    XP_054215076.1
    XP_054215077.1
    XP_054215078.1
    XP_054215079.1
    XP_054215080.1
    XP_054215081.1
    XP_054215082.1
    XP_054215083.1
    XP_054215084.1
    XP_054215085.1
    XP_054215086.1
    XP_054215087.1
    XP_054215088.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029407.1 RefSeqGene

      Range
      5038..113478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001220.5 → NP_001211.3  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1

      See identical proteins and their annotated locations for NP_001211.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC006454, AK290148, BI550751, U23460
      Consensus CDS
      CCDS5483.1
      UniProtKB/Swiss-Prot
      A4D2K0, A4D2K1, A4D2K2, A4D2K3, A4D2K4, A4D2K5, A4D2K6, O95437, O95438, O95599, Q13554, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4
      UniProtKB/TrEMBL
      A0A8V8TQ39, A4D2J9
      Related
      ENSP00000379098.2, ENST00000395749.7
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:534 → 661
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    2. NM_001293170.2 → NP_001280099.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

      See identical proteins and their annotated locations for NP_001280099.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks multiple alternate in-frame exons in the 3' coding region and differs in the 3' UTR, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Variants 2 and 9 encode the same protein (isoform 2).
      Source sequence(s)
      AF078803, AK290148, AK294138, BI550751, BQ130578
      Consensus CDS
      CCDS5484.1
      UniProtKB/TrEMBL
      Q53H78
      Related
      ENSP00000326375.5, ENST00000350811.7
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:410 → 537
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    3. NM_172078.3 → NP_742075.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

      See identical proteins and their annotated locations for NP_742075.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (2) that is missing an internal segment compared to isoform 1. Variants 2 and 9 encode the same protein (isoform 2).
      Source sequence(s)
      AC006454, AF078803, AK290148, BI550751
      Consensus CDS
      CCDS5484.1
      UniProtKB/TrEMBL
      Q53H78
      Related
      ENSP00000397937.2, ENST00000440254.6
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:410 → 537
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    4. NM_172079.3 → NP_742076.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3

      See identical proteins and their annotated locations for NP_742076.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as beta 4, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), also known as beta 4 subunit, that is missing an internal segment compared to isoform 1.
      Source sequence(s)
      AC006454, AJ252238, AK290148, BI550751, BX445032, DB566810
      Consensus CDS
      CCDS5485.1
      UniProtKB/TrEMBL
      Q53H78
      Related
      ENSP00000379096.2, ENST00000395747.6
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:386 → 513
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    5. NM_172080.3 → NP_742077.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 4

      See identical proteins and their annotated locations for NP_742077.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as beta e, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (4), also known as beta e subunit, that is missing an internal segment compared to isoform 1.
      Source sequence(s)
      AC006454, AF083419, AK290148, BI550751
      Consensus CDS
      CCDS43573.1
      UniProtKB/TrEMBL
      Q53H78
      Related
      ENSP00000258682.6, ENST00000258682.10
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:385 → 512
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    6. NM_172081.3 → NP_742078.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 5

      See identical proteins and their annotated locations for NP_742078.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as beta e', lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (5), also known as beta e' subunit, that is missing an internal segment compared to isoform 1.
      Source sequence(s)
      AC006454, AK290148, BC019070
      Consensus CDS
      CCDS5486.1
      UniProtKB/TrEMBL
      Q53H78
      Related
      ENSP00000351542.3, ENST00000358707.7
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:371 → 498
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    7. NM_172082.3 → NP_742079.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 6

      See identical proteins and their annotated locations for NP_742079.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as beta 6, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (6), also known as beta 6 subunit, that is missing an internal segment compared to isoform 1.
      Source sequence(s)
      AC006454, AF081924, AK290148, BI550751
      Consensus CDS
      CCDS5487.1
      UniProtKB/TrEMBL
      A0A8V8TR22
      Related
      ENSP00000326544.6, ENST00000347193.8
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      cl09109
      Location:386 → 487
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    8. NM_172083.3 → NP_742080.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 7

      See identical proteins and their annotated locations for NP_742080.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), also known as beta 2, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (7), also known as beta 2 subunit, that is missing an internal segment compared to isoform 1.
      Source sequence(s)
      AA399393, AC006454, AJ252236, AK290148, BI550751, DA069361, DB175099
      Consensus CDS
      CCDS5488.1
      UniProtKB/TrEMBL
      Q53H78
      Related
      ENSP00000326427.5, ENST00000353625.8
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:347 → 474
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    9. NM_172084.3 → NP_742081.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 8

      See identical proteins and their annotated locations for NP_742081.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), also known as beta 7, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (8), also known as beta 7 subunit, that is missing an internal segment compared to isoform 1.
      Source sequence(s)
      AC006454, AK290148, BI550751, BX445032, DB566810
      Consensus CDS
      CCDS5489.1
      UniProtKB/TrEMBL
      Q53H78
      Related
      ENSP00000326518.5, ENST00000346990.8
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:317 → 444
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      44217154..44326013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515559.3 → XP_011513861.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X19

      See identical proteins and their annotated locations for XP_011513861.1

      Conserved Domains (3) summary
      smart00220
      Location:1 → 143
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam08332
      Location:448 → 575
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1 → 174
      PKc_like; Protein Kinases, catalytic domain

    2. XM_017012665.2 → XP_016868154.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X24

      UniProtKB/TrEMBL
      Q53H78
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:361 → 488
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    3. XM_011515557.2 → XP_011513859.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X11

      UniProtKB/TrEMBL
      A0A8V8TQR5
      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:528 → 655
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    4. XM_017012664.2 → XP_016868153.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X22

      UniProtKB/TrEMBL
      Q53H78
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:370 → 497
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    5. XM_006715781.3 → XP_006715844.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X26

      UniProtKB/TrEMBL
      A0A8V8TQR5
      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:494 → 621
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    6. XM_011515554.2 → XP_011513856.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8

      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:537 → 664
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    7. XM_017012662.2 → XP_016868151.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X17

      UniProtKB/TrEMBL
      A0A8V8TQR5

    8. XM_011515552.2 → XP_011513854.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5

      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:552 → 679
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    9. XM_005249864.4 → XP_005249921.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X23

      See identical proteins and their annotated locations for XP_005249921.1

      UniProtKB/TrEMBL
      Q53H78
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:362 → 489
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    10. XM_011515556.2 → XP_011513858.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X10

      UniProtKB/TrEMBL
      A0A8V8TQR5
      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:529 → 656
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    11. XM_047420882.1 → XP_047276838.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X18

      UniProtKB/TrEMBL
      A0A8V8TQR5

    12. XM_047420881.1 → XP_047276837.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X15

      UniProtKB/TrEMBL
      A0A8V8TQR5

    13. XM_017012660.2 → XP_016868149.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7

    14. XM_047420880.1 → XP_047276836.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X13

      UniProtKB/TrEMBL
      A0A8V8TQ39

    15. XM_011515550.2 → XP_011513852.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X3

      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:553 → 680
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    16. XM_006715784.3 → XP_006715847.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X21

      See identical proteins and their annotated locations for XP_006715847.1

      UniProtKB/TrEMBL
      Q53H78
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:386 → 513
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    17. XM_011515551.2 → XP_011513853.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4

      UniProtKB/TrEMBL
      A0A8V8TQR5
      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:553 → 680
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    18. XM_005249862.4 → XP_005249919.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X20

      See identical proteins and their annotated locations for XP_005249919.1

      UniProtKB/TrEMBL
      Q53H78
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:395 → 522
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    19. XM_017012661.2 → XP_016868150.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X12

      UniProtKB/TrEMBL
      A0A8V8TQR5

    20. XM_011515549.2 → XP_011513851.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:562 → 689
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    21. XM_024446945.2 → XP_024302713.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X14

      UniProtKB/TrEMBL
      A0A8V8TQR5
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:496 → 623
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    22. XM_011515553.2 → XP_011513855.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X6

      UniProtKB/TrEMBL
      A0A8V8TQR5
      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:539 → 666
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    23. XM_011515555.2 → XP_011513857.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X9

      UniProtKB/TrEMBL
      A0A8V8TQ39
      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:534 → 661
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    24. XM_011515547.2 → XP_011513849.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1

      See identical proteins and their annotated locations for XP_011513849.1

      Conserved Domains (3) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:577 → 704
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    25. XM_047420883.1 → XP_047276839.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X25

      UniProtKB/TrEMBL
      A0A8V8TQ13
      Related
      ENSP00000514922.1, ENST00000700291.1

    26. XM_011515558.3 → XP_011513860.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X16

      Conserved Domains (2) summary
      smart00220
      Location:14 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      44375741..44485432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359106.1 → XP_054215081.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X19

    2. XM_054359111.1 → XP_054215086.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X24

      UniProtKB/TrEMBL
      Q53H78

    3. XM_054359098.1 → XP_054215073.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X11

      UniProtKB/TrEMBL
      A0A8V8TQR5

    4. XM_054359109.1 → XP_054215084.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X22

      UniProtKB/TrEMBL
      Q53H78

    5. XM_054359113.1 → XP_054215088.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X26

      UniProtKB/TrEMBL
      A0A8V8TQR5

    6. XM_054359095.1 → XP_054215070.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8

    7. XM_054359104.1 → XP_054215079.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X17

      UniProtKB/TrEMBL
      A0A8V8TQR5

    8. XM_054359092.1 → XP_054215067.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5

    9. XM_054359110.1 → XP_054215085.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X23

      UniProtKB/TrEMBL
      Q53H78

    10. XM_054359097.1 → XP_054215072.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X10

      UniProtKB/TrEMBL
      A0A8V8TQR5

    11. XM_054359105.1 → XP_054215080.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X18

      UniProtKB/TrEMBL
      A0A8V8TQR5

    12. XM_054359102.1 → XP_054215077.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X15

      UniProtKB/TrEMBL
      A0A8V8TQR5

    13. XM_054359094.1 → XP_054215069.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7

    14. XM_054359100.1 → XP_054215075.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X13

      UniProtKB/TrEMBL
      A0A8V8TQ39

    15. XM_054359090.1 → XP_054215065.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X3

    16. XM_054359108.1 → XP_054215083.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X21

      UniProtKB/TrEMBL
      Q53H78

    17. XM_054359091.1 → XP_054215066.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4

      UniProtKB/TrEMBL
      A0A8V8TQR5

    18. XM_054359107.1 → XP_054215082.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X20

      UniProtKB/TrEMBL
      Q53H78

    19. XM_054359099.1 → XP_054215074.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X12

      UniProtKB/TrEMBL
      A0A8V8TQR5

    20. XM_054359089.1 → XP_054215064.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2

    21. XM_054359101.1 → XP_054215076.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X14

      UniProtKB/TrEMBL
      A0A8V8TQR5

    22. XM_054359093.1 → XP_054215068.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X6

      UniProtKB/TrEMBL
      A0A8V8TQR5

    23. XM_054359096.1 → XP_054215071.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X9

      UniProtKB/TrEMBL
      A0A8V8TQ39

    24. XM_054359088.1 → XP_054215063.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1

    25. XM_054359112.1 → XP_054215087.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X25

      UniProtKB/TrEMBL
      A0A8V8TQ13

    26. XM_054359103.1 → XP_054215078.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X16

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13554.3 GenPept UniProtKB/Swiss-Prot:Q13554

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