C32D5.11 RING-type E3 ubiquitin transferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: C32D5.11
Official Full Name: RING-type E3 ubiquitin transferase
Primary source: WormBase:WBGene00016318
Locus tag: CELE_C32D5.11
See related: AllianceGenome:WB:WBGene00016318
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable transferase activity and zinc ion binding activity. Predicted to be involved in protein import into peroxisome matrix. Predicted to be located in peroxisomal membrane. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 6B and peroxisome biogenesis disorder 6A. Orthologous to human PEX10 (peroxisomal biogenesis factor 10). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See C32D5.11 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 11

Sequence:: Chromosome: II; NC_003280.10 (6352530..6355446, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C32D5.11 (e-PCR)
- UniSTS:309206

C32D5.12 (e-PCR)
- UniSTS:309207

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peroxisome organization	IEA Inferred from Electronic Annotation more info
involved_in protein import into peroxisome matrix	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RING-type E3 ubiquitin transferase

NP_001364718.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6352530..6355446 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001377807.3 → NP_001364718.1 RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q18355

Conserved Domains (2) summary

COG5432
Location:24 → 114

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cl17238
Location:26 → 68

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain