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    cdka-1 Cyclin-dependent kinase 5 activator 1 [ Caenorhabditis elegans ]

    Gene ID: 188812, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdka-1
    Official Full Name
    Cyclin-dependent kinase 5 activator 1
    Primary source
    WormBase:WBGene00011955
    Locus tag
    CELE_T23F11.3
    See related
    AllianceGenome:WB:WBGene00011955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and protein kinase binding activity. Involved in several processes, including GABAergic synaptic transmission; regulation of dense core granule transport; and synaptic vesicle transport. Predicted to be located in axon cytoplasm; dendrite; and synapse. Predicted to be part of protein kinase 5 complex. Predicted to be active in cytoplasm and growth cone. Used to study epilepsy and lissencephaly. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1) and CDK5R2 (cyclin dependent kinase 5 regulatory subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdka-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (4658794..4662702)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin ligase activity inhibits Cdk5 to control axon termination. Desbois M, et al. PLoS Genet, 2022 Apr. PMID 35421092, Free PMC Article
    2. Effect of dys-1 mutation on gene expression profile in space-flown Caenorhabditis elegans. Xu D, et al. Muscle Nerve, 2018 Jan 18. PMID 29346705
    3. CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis elegans. Juo P, et al. Mol Biol Cell, 2007 Oct. PMID 17671168, Free PMC Article
    4. Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons. Goodwin PR, et al. J Neurosci, 2012 Jun 13. PMID 22699897, Free PMC Article
    5. Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism. Park EC, et al. EMBO J, 2012 Mar 21. PMID 22252129, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dense core granule transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein kinase 5 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin-dependent kinase 5 activator 1
    NP_001076649.1
    • Confirmed by transcript evidence
    NP_001076650.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4658794..4662702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083181.6 → NP_001076650.1  Cyclin-dependent kinase 5 activator 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076650.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22695
      Conserved Domains (1) summary
      pfam03261
      Location:18 → 362
      CDK5_activator; Cyclin-dependent kinase 5 activator protein

    2. NM_001083180.4 → NP_001076649.1  Cyclin-dependent kinase 5 activator 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076649.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0G843, Q22695
      Conserved Domains (1) summary
      pfam03261
      Location:18 → 352
      CDK5_activator; Cyclin-dependent kinase 5 activator protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22695.2

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