vps-16 Vacuolar protein sorting-associated protein 16 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vps-16
Official Full Name: Vacuolar protein sorting-associated protein 16 homolog
Primary source: WormBase:WBGene00006516
Locus tag: CELE_C05D11.2
See related: AllianceGenome:WB:WBGene00006516
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin binding activity. Involved in digestive tract development and embryo development. Predicted to be located in late endosome membrane and lysosomal membrane. Predicted to be part of HOPS complex. Predicted to be active in endosome. Human ortholog(s) of this gene implicated in dystonia 30. Orthologous to human VPS16 (VPS16 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See vps-16 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (6433239..6436502)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C05D11.3 (e-PCR)
- UniSTS:320453

C05D11.2 (e-PCR)
- UniSTS:308474

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	NAS Non-traceable Author Statement more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vacuole fusion, non-autophagic	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuole organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of HOPS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of HOPS complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	NAS Non-traceable Author Statement more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Vacuolar protein sorting-associated protein 16 homolog

NP_498411.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6433239..6436502

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066010.6 → NP_498411.1 Vacuolar protein sorting-associated protein 16 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498411.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q11182

Conserved Domains (2) summary

pfam04841
Location:20 → 430

Vps16_N; Vps16, N-terminal region

pfam04840
Location:535 → 825

Vps16_C; Vps16, C-terminal region