jmjd-3.1 JmjC domain-containing protein;Lysine-specific demethylase jmjd-3.1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: jmjd-3.1
Official Full Name: JmjC domain-containing protein;Lysine-specific demethylase jmjd-3.1
Primary source: WormBase:WBGene00017571
Locus tag: CELE_F18E9.5
See related: AllianceGenome:WB:WBGene00017571
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables histone H3K27me2/H3K27me3 demethylase activity. Involved in transdifferentiation. Located in nucleus. Is expressed in PDA and Y cell. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See jmjd-3.1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (8571049..8575451)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

targeting of the Jumonji demethylases JMJD-2 and JMJD-3/UTX-1 restores H3K9me3 and H3K27me3 levels, respectively, and it fully alleviates the bisphenol A-induced transgenerational effects
Title: The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1.
Study demonstrates that both jmjd-1.2 and jmjd-3.1 are necessary and sufficient for activation of the UPRmt in C. elegans and identifies jmjd-1.2 and jmjd-3.1 as positive regulators of a longevity response that genetically requires UPRmt signaling.
Title: Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.
study reports that JMJD-3.1 and the H3K4 methyltransferase Set1 complex cooperate to ensure invariant transdifferentiation (Td) of postmitotic Caenorhabditis elegans hindgut cells into motor neurons
Title: Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F18E9.5 (e-PCR)
- UniSTS:312265

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27me2/H3K27me3 demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K27me2/H3K27me3 demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K27me2/H3K27me3 demethylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in transdifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MLL3/4 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: JmjC domain-containing protein;Lysine-specific demethylase jmjd-3.1

NP_001367710.1

Confirmed by transcript evidence

NP_509451.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

8571049..8575451

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381042.1 → NP_001367710.1 JmjC domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q19565

Conserved Domains (2) summary

smart00558
Location:723 → 787

JmjC; A domain family that is part of the cupin metalloenzyme superfamily

pfam02373
Location:757 → 865

JmjC; JmjC domain, hydroxylase
NM_077050.7 → NP_509451.2 Lysine-specific demethylase jmjd-3.1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509451.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95QK3

Conserved Domains (2) summary

pfam02373
Location:798 → 906

JmjC; JmjC domain, hydroxylase

smart00558
Location:764 → 828

JmjC; A domain family that is part of the cupin metalloenzyme superfamily