nft-1 Nitrilase homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nft-1
Official Full Name: Nitrilase homolog
Primary source: WormBase:WBGene00003594
Locus tag: CELE_Y56A3A.13
See related: AllianceGenome:WB:WBGene00003594
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable bis(5'-adenosyl)-triphosphatase activity and deaminated glutathione amidase activity. Predicted to be involved in amide catabolic process and nucleobase-containing compound metabolic process. Is expressed in intestine; nervous system; and tail. Orthologous to human NIT1 (nitrilase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nft-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (11923886..11929378)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y56A3A.13 (e-PCR)
- UniSTS:321761

Y56A3A.23 (e-PCR)
- UniSTS:321767

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables bis(5'-adenosyl)-triphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables bis(5'-adenosyl)-triphosphatase activity	IEA Inferred from Electronic Annotation more info
enables bis(5'-adenosyl)-triphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables deaminated glutathione amidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amide catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleobase-containing compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleobase-containing compound metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: Nitrilase homolog

NP_499556.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

11923886..11929378

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067155.9 → NP_499556.1 Nitrilase homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499556.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76463

Conserved Domains (2) summary

cd07572
Location:17 → 281

nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)

cd01275
Location:300 → 418

FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...