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    mab-21 Protein male abnormal 21 [ Caenorhabditis elegans ]

    Gene ID: 175607, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mab-21
    Official Full Name
    Protein male abnormal 21
    Primary source
    WormBase:WBGene00003112
    Locus tag
    CELE_F35G12.6
    See related
    AllianceGenome:WB:WBGene00003112
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in cell fate commitment; embryo development; and nematode male tail mating organ morphogenesis. Is expressed in body wall musculature; hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in coloboma and syndromic microphthalmia 14. Orthologous to human MAB21L1 (mab-21 like 1) and MAB21L2 (mab-21 like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mab-21 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (4600753..4603052)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Anaphase-promoting complex subunit 11 Neighboring gene ATP synthase F(0) complex subunit B1, mitochondrial Neighboring gene BEACH domain-containing protein;Putative neurobeachin homolog Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Postembryonic expression of Caenorhabditis elegans mab-21 and its requirement in sensory ray differentiation. Ho SH, et al. Dev Dyn, 2001 Aug. PMID 11500979
    2. Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity. Del Rosario JS, et al. BMC Neurosci, 2015 Apr 23. PMID 25899010, Free PMC Article
    3. HOM-C/Hox genes and four interacting loci determine the morphogenetic properties of single cells in the nematode male tail. Chow KL, et al. Development, 1994 Sep. PMID 7956833
    4. Pattern formation in the nematode epidermis: determination of the arrangement of peripheral sense organs in the C. elegans male tail. Baird SE, et al. Development, 1991 Oct. PMID 1782863
    5. The mab-21 gene of Caenorhabditis elegans encodes a novel protein required for choice of alternate cell fates. Chow KL, et al. Development, 1995 Nov. PMID 8582275

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode male tail mating organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein male abnormal 21
    NP_497940.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4600753..4603052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065539.7 → NP_497940.2  Protein male abnormal 21 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497940.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17337, Q20054
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20054.2

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